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Breaking News: 100 days of uncertaintySee today's BioWorld Science
Home » Targeting translation could be novel way to fight Myc, other oncogenes
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Cancer

Targeting translation could be novel way to fight Myc, other oncogenes

Feb. 4, 2025
By Anette Breindl
Researchers at the University of California at San Francisco have identified an RNA-binding protein that increased the translation of Myc mRNA. The authors wrote that their work, which was published online in Nature Cell Biology on Feb. 4, 2025, “transforms the understanding of the translational code in cancer and illuminates therapeutic openings to target the expression of oncogenes.” Myc is a transcription factor that regulates multiple cellular growth factors. Its overexpression is a driver event in many solid tumors, including pancreatic cancer. Drugging Myc, though, has so far proved challenging.
BioWorld Science Cancer

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