Merck Sharp & Dohme prepares new KRAS G12D degrader PROTACs

Feb. 13, 2025

Merck Sharp & Dohme LLC patents report the development of proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase (Von Hippel-Lindau disease tumor suppressor [VHL] ligands) coupled to GTPase KRAS (G12D mutant)-targeting moiety through a linker.

BioWorld Science Cancer Patents

Today's news in brief

BioWorld

BioWorld briefs for March 17, 2025.

Today's news in brief

BioWorld MedTech

BioWorld MedTech briefs for March 17, 2025

Clinical trial fraud ends with guilty pleas

BioWorld

In another real-life episode of “sponsor beware,” the owners of a clinical research facility pleaded guilty March 10 in U.S. district court to fraud charges...

At CROI, HIV cure trials raise hopes for broader applicability

BioWorld

At the 2025 meeting of the Conference on Retroviruses and Opportunistic Infections (CROI) it was the best of times, it was the worst of times. On the first full...

Hummingbird migrates ADCs, tech to newco Callio’s $187M debut

BioWorld

Antibody-drug conjugate (ADC)-focused Callio Therapeutics debuted on March 3 with the closing of a $187 million series A financing round based on cancer drug...