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Breaking News: Trump administration impacts continue to roil the life sciences sectorSee today's BioWorld Science
Home » AGR2 modulation ameliorates IBD phenotype
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Gastrointestinal

AGR2 modulation ameliorates IBD phenotype

Feb. 21, 2025
Anterior gradient 2 (AGR2) is a protein located in the endoplasmic reticulum involved in protein folding and when stressed, it is secreted into the extracellular space and it attracts monocytes, activates fibroblasts and disrupts the epithelial integrity. The relationship between the expression of AGR2 in tissues from patients with inflammatory bowel disease (IBD) was investigated, as well as the efficacy of an anti-AGR2 antibody in murine models of colon inflammation and fibrosis.
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