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Home » Opthea in freefall after phase III fail in wet AMD
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Opthea in freefall after phase III fail in wet AMD

March 25, 2025
By Tamra Sami
Opthea Ltd. is considering its options after lead candidate sozinibercept (OPT-302) failed the phase III Coast trial in wet age-related macular degeneration (AMD). The global Coast phase III trial evaluated the efficacy and safety of intravitreally administered 2-mg sozinibercept every four or eight weeks in combination with 2-mg aflibercept every eight weeks after a loading phase for the treatment of wet AMD. The trial did not meet its primary endpoint of mean change in best corrected visual acuity from baseline to week 52.
BioWorld Asia Clinical Ocular Protein Asia-Pacific Australia

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