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Home » Street can a-GRI on phase IIb safety win in IPF with tazarotene
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Street can a-GRI on phase IIb safety win in IPF with tazarotene

April 1, 2025
By Randy Osborne
GRI Bio Inc.’s oral version of tazarotene is showing phase IIa promise in idiopathic pulmonary fibrosis (IPF). The peek at interim safety with the compound, a RAR-βɣ dual agonist designed to inhibit the activity of human type 1 invariant natural killer T cells, consisted of a preplanned analysis of two-week results in the biomarker study. GRI-0621 at 4.5 mg once daily proved safe and well-tolerated in the first 12 patients.
BioWorld Clinical Respiratory Small molecule U.S.

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