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Home » Biontech trades half of bispecific BNT-327 to BMS for potential $11B+
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Biontech trades half of bispecific BNT-327 to BMS for potential $11B+

June 2, 2025
By Brian Orelli
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Biontech SE and Bristol Myers Squibb Co. are teaming up to develop Biontech’s BNT-327 in a deal possibly worth over $11 billion. BNT-327 is in the hot new class of bispecific antibodies targeting programmed death-1 (PD-1) or its ligand (PD-L1) and vascular endothelial growth factor (VEGF). The bispecifics take advantage of two well established mechanisms of action that help tumors grow; PD-1/PD-L1, which tells immunogenic T cells not to attack the tumor, and VEGF, which tumors excrete to produce new blood vessels to supply oxygen and other nutrients to the tumor.
BioWorld Deals and M&A Cancer Bispecific antibody Europe U.S.

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