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Home » immuno-oncology

Articles Tagged with ''immuno-oncology''

Hand holding "Acquisition" piece over puzzle

Pfizer bets on CD47 blockade in cancer with $2.3B Trillium bid

Aug. 23, 2021
By Cormac Sheridan
Pfizer Inc. has turned up the temperature in the already hot CD47 inhibitor space by offering $18.50 per share or $2.26 billion cash to acquire Trillium Therapeutics Inc., a biotech with two clinical-stage CD47 inhibitors.
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Macrophage and cancer cell
Newco news

Macomics aiming to harness full potential of TAM biology

Aug. 9, 2021
By Nuala Moran
LONDON – Newco Macomics Ltd. has closed its first financing round at £7.4 million (US$10.3 million), enabling it to lay the ground for a new approach to addressing immunosuppression in the tumor microenvironment by modulating disease-specific macrophages.
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Hand holding dollar sign

T-knife adds $110M series B to advance mouse-generated TCR platform

Aug. 2, 2021
By Nuala Moran
LONDON – T-knife Therapeutics GmbH closed a $110 million series B, as it advances plans for the phase I/II trial of its first fully human T-cell receptor (TCR) in the treatment of solid tumors, which is due to start later this year.
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Zai Lab and Macrogenics partner in $1.5B cancer deal

June 16, 2021
By Richard Staines
Zai Lab Ltd. and Macrogenics Inc. have announced a collaboration and license agreement involving up to four immuno-oncology molecules in a deal potentially worth upward of $1.5 billion. The deal makes sense as both are upcoming companies at around the same stage in development – making progress in oncology with first products recently approved by regulators.
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Bright Peak closes $107M series B round as engineered cytokine space heats up

June 10, 2021
By Cormac Sheridan
Bright Peak Therapeutics Inc. closed a $107 million series B round to progress a pipeline of engineered cytokines, which are produced using a chemical synthesis method instead of classical recombinant protein production approaches.
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Handshake with digital globe overlay

Veracyte bolsters diagnostic cancer offerings with $318M Haliodx buy

June 1, 2021
By Meg Bryant
Veracyte Inc. has agreed to acquire Haliodx SAS in a €260 million (US$318.1 million) deal to accelerate growth and strengthen its global footprint in cancer diagnostics. The cash and stock transaction will give Veracyte a manufacturing presence in Europe and expand its cancer diagnostics scope to eight of the 10 top cancers by U.S. incidence.
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Antibodies

Numab lays down a marker in immuno-oncology with $111M series C round

May 20, 2021
By Cormac Sheridan
DUBLIN – Numab Therapeutics AG has moved closer to the front rank of European antibody developers by raising CHF100 million (US$111 million) in a series C financing round to accelerate the development of NM21-1480, a trispecific antibody that acts both as a PD-L1 inhibitor and 4-1BB (CD137) agonist. It also contains a human serum albumin recognition group, to extend its circulatory half-life. 
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Antibodies attacking cancer cell

TIGIT fidgets lessen as Agenus’ mystery preclinical bispecific bags BMS pact worth up to $1.3B-plus

May 18, 2021
By Randy Osborne
The anti-TIGIT bispecific antibody AGEN-1777’s preclinical status didn’t stand in the way of Bristol Myers Squibb Co.’s whopper deal with Agenus Inc., which is collecting $200 million up front and as much as $1.36 billion in potential milestone payments in trade for development and commercial rights to the Fc-enhanced compound.
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T cells

Appia Bio closes $52M series A round to lead the way on CAR-iNKT cell therapy

May 11, 2021
By Cormac Sheridan
Appia Bio Inc. raised $52 million in a series A funding round to bring forward a novel take on allogeneic cell therapy for cancer, based on a rare lymphocyte population, invariant natural killer T (iNKT) cells, which exhibit aspects of both NK cell and T-cell biology.
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Xilio advancing immunotherapies to the clinic with $95M series C

Feb. 25, 2021
By Michael Fitzhugh
Cancer immunotherapy developer Xilio Therapeutics Inc. has raised $95 million in series C financing to support its efforts to move a duo of tumor-selective candidates into the clinic. IND applications for both its interleukin-2 agonist, XTX-202, and anti-cytotoxic T-lymphocyte-associated protein 4 antibody, XTX-101, are planned for this year.
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