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Home » CRISPR

Articles Tagged with ''CRISPR''

Cells, DNA illustration

Caribou Biosciences raises $115M series C to advance CRISPR tech, cell therapy pipeline

March 3, 2021
By Michael Fitzhugh
Berkeley, Calif.-based Caribou Biosciences Inc. has raised $115 million in an oversubscribed series C financing co-led by Farallon Capital Management, PFM Health Sciences and Ridgeback Capital Investments. Proceeds from the round will be used to advance its CRISPR technology platform and pipeline of off-the-shelf genome-edited CAR T and CAR-NK cell cancer therapies, including CB-010, its lead CAR T program, now in a phase I trial for patients with relapsed/refractory B-cell non-Hodgkin lymphoma.
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Gene editing illustration

Excision adds a $60M funding to develop CRISPR-based therapies

Feb. 17, 2021
By Lee Landenberger
Excision Biotherapeutics Inc.’s CEO is specific when he talks about his company’s therapies and what they may achieve: a functional cure. “When you treat someone and they become cancer free, you can’t use the world ‘cured’ because the cancer may come back decades later,” Daniel Dornbusch told BioWorld. “But you can talk about a  functional cure, meaning the cancer didn’t come back for a very long time. It’s functionally cured for maybe 10, 20 or 30 years."
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Optogenetics illustration

HELP is on its way for herpetic stromal keratitis

Jan. 19, 2021
By John Fox
Transient gene editing of the herpes simplex virus type 1 using mRNA-based CRISPR was shown for the first time to be effective against herpetic stromal keratitis in mice and blocked HSV-1 replication in human corneas, Chinese researchers reported in the January 11, 2021, online edition of Nature Biotechnology.
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2020 pandemic illustration

2020 Year in Review: The non-COVID version

Dec. 31, 2020
It might be difficult to view the past year through anything other than a COVID-shaped hole. But 2020 brought some remarkable and impactful news for the biopharma sector that had little to do with the novel coronavirus. In this end-of-year recap, BioWorld takes a look at some of achievements and trends affecting the industry that were completely unrelated to – or, in some cases, in spite of – the COVID-19 pandemic.
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Metagenomi launches with $65M series A and long leash in gene editing

Nov. 12, 2020
By Lee Landenberger
Metagenomi Inc. has raised a $65 million series A financing to expand its gene editing abilities, advance its research and validate its pipeline in preclinical studies. The company’s CRISPR-based systems use algorithms for screening thousands of genomes from microorganisms to advance therapies for use in oncology, genetic diseases and possibly much more.
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Acquisition target

Perkinelmer snags Horizon Discovery for $383M

Nov. 2, 2020
By Meg Bryant
Perkinelmer Inc. is looking to bolster its life sciences offerings with the purchase of cell engineering company Horizon Discovery Group plc for $383 million. The all-cash acquisition will add gene-editing and gene-modulation tools to Perkinelmer’s existing portfolio of discovery and applied genomics solutions. Headquartered in Cambridge, U.K., Horizon provides CRISPR and RNA interference (RNAi) reagents, cell models, cell engineering and based editing products to aid in drug discovery and development.
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Adenovirus cells

"Foundational" research shows early gene therapy prevents Angelman syndrome

Oct. 30, 2020
By W. Todd Penberthy
Scientists working at the University of North Carolina, Chapel Hill reported in the Oct. 21, 2020, issue of Nature on the successful development of a one-time specific sequence-directed gene therapy approach using the combination of AAV with CRISPR technology that successfully prevented the presentation of Angelman syndrome throughout the lifetime of a mouse model.
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Crispr posts solid early stage allogeneic CAR T data marred by a death in the study

Oct. 21, 2020
By Brian Orelli
Crispr Therapeutics AG's first stab at developing an allogeneic CAR T-cell therapy, CTX-110, looks promising, but the efficacy data were overshadowed by a death in the study.
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Nobel Prize in Chemistry illustration
Three’s a crowd?

Doudna-Charpentier duo is sole winner of chemistry Nobel

Oct. 7, 2020
By Anette Breindl
Surprising no one, Jennifer Doudna and Emmanuelle Charpentier won the 2020 Nobel Prize in Chemistry “for the development of a method for genome editing,” that is, the CRISPR/Cas9 system.
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Nobel Prize in Chemistry illustration
Three’s a crowd

Doudna-Charpentier duo is sole winner of chemistry Nobel

Oct. 7, 2020
By Anette Breindl
Surprising no one, Jennifer Doudna and Emmanuelle Charpentier won the 2020 Nobel Prize in Chemistry “for the development of a method for genome editing,” that is, the CRISPR/Cas9 system.
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