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Home » Janssen Pharmaceutica NV

Articles Tagged with ''Janssen Pharmaceutica NV''

Infection

JNJ-9117, a potent pan-genotype HEV replication inhibitor with promising antiviral profile

June 12, 2024
At last week’s EASL meeting, Janssen Pharmaceutica NV disclosed the discovery and preclinical evaluation of a novel pan-genotypic hepatitis E virus (HEV) replication inhibitor, JNJ-64779117 (JNJ-9117).
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HIV/AIDS

CoPoP liposomes presenting stabilized HIV-1 Env trimers elicit multiclade neutralization in rabbits

May 3, 2024
Novel HIV-1 vaccine strategies should elicit potent and broad immunity against the viral envelope (Env) glycoprotein. Particle presentation of Env has shown promise in animal studies, but has several problems that limit their clinical application.
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Microscope with beakers and flasks
Drug Design, Drug Delivery & Technologies

Odyssey Therapeutics and Janssen Pharmaceutica enter drug discovery collaboration

April 5, 2024
Odyssey Therapeutics Inc. has entered into a strategic research collaboration with Janssen Pharmaceutica NV, a Johnson & Johnson company, to jointly discover and optimize small-molecule medicines against select therapeutic targets.
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Lianbio shuttering operations, after rejecting Concentra

Feb. 20, 2024
By Tamra Sami
After Lianbio Co. Ltd. turned away a $465 million acquisition offer from Concentra Biosciences LLC, the China and U.S.-based biotech announced it was selling off its assets and shutting down the company.
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Lianbio shuttering operations, after rejecting Concentra

Feb. 14, 2024
By Tamra Sami
After Lianbio Co. Ltd. turned away a $465 million acquisition offer from Concentra Biosciences LLC, the China and U.S.-based biotech announced it was selling off its assets and shutting down the company.
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Infection

Janssen Pharmaceutica patent discloses new compounds for SARS-CoV-2 infection

Feb. 7, 2024
Janssen Pharmaceutica NV researchers have identified new compounds for the treatment of SARS-CoV-2 infection (COVID-19).
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Lianbio out-licenses Asia rights to Janssen for radioenhancer NBTXR-3 for $30M

Jan. 2, 2024
By Tamra Sami
Lianbio Co. Ltd. is out-licensing NBTXR-3 to Janssen Pharmaceutical NV to develop and commercialize the radioenhancer in China, South Korea, Singapore and Thailand. Earlier this month, Tang Capital’s Concentra Biosciences LLC lodged a proposal to acquire Lianbio for $465 million, which the company’s shareholders rejected.
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Lianbio out-licenses Asia rights to Janssen for radioenhancer NBTXR-3 for $30M

Dec. 27, 2023
By Tamra Sami
Lianbio Co. Ltd. is out-licensing NBTXR-3 to Janssen Pharmaceutical NV to develop and commercialize the radioenhancer in China, South Korea, Singapore and Thailand. Earlier this month, Tang Capital’s Concentra Biosciences LLC lodged a proposal to acquire Lianbio for $465 million, which the company’s shareholders rejected.
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Cancer

Janssen Pharmaceutica describes new MAP3K14 inhibitors for cancer

Dec. 7, 2023
Janssen Pharmaceutica NV had disclosed new pyrrolidinone derivatives acting as NF-κB-inducing kinase (NIK; MAP3K14) inhibitors and reported to be useful for the treatment of cancer.
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Pipet, test tubes, chemical structures
Neurology/Psychiatric

Discovery of novel MAGL inhibitor with excellent brain penetration and oral bioavailability

Sep. 4, 2023
Monoacylglycerol lipase (MAGL), a member of the serine hydrolase family expressed in the brain and peripheral tissue, is a key enzyme in the hydrolysis of monoglycerides, converting 2-arachidonoyl glycerol (2-AG) into arachidonic acid and glycerol. MAGL inhibition has been previously shown to induce anxiolytic and analgesic phenotypes in animal models. Researchers from Janssen Pharmaceutica NV recently reported the discovery of novel noncovalent MAGL inhibitors.
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