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Home » leukemia

Articles Tagged with ''leukemia''

Killer T cells surround a cancer cell.
Cancer

Leukemia-related rogue immune cells cause autoimmune disorders

Nov. 30, 2022
By Mar de Miguel
Does cancer cause autoimmune disease or is it the other way around? In looking at the question of which comes first, the chicken or the egg, researchers at the Garvan Institute of Medical Research in Australia found that a genetic mutation that alters immune cells in leukemia is behind certain autoimmune disorders.
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Cancer

Chengdu Easton Biopharmaceuticals discovers new BRD4-targeting PROTACs

Nov. 25, 2022
Chengdu Easton Biopharmaceuticals Co. Ltd. has described proteolysis targeting chimera (PROTAC) compounds comprising a cereblon (CRBN) ligand binding moiety covalently bound to a bromodomain-containing protein 4 (BRD4; HUNK1)-targeting moiety through a linker.
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Cancer

Parenchyma Biotech presents new AhR agonists

Oct. 27, 2022
Parenchyma Biotech Inc. has described aryl hydrocarbon receptor (AhR) agonists reported to be useful for the treatment of cancer and autoimmune disease.
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Leukemia illustration

HKSH adopts droplet digital PCR in monitoring for leukemia patients

Oct. 20, 2022
By Doris Yu
HKSH Medical Group (HKSH) has adopted droplet digital polymerase chain reaction (ddPCR) for minimal residual disease (MRD) monitoring to track the status of patients with leukemia.
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Cancer

PROTACs targeting LCK show promise in T-cell acute lymphoblastic leukemia models

Oct. 10, 2022
Targeting tyrosine-protein kinase Lck (LCK) with dasatinib has demonstrated activity against T-cell acute lymphoblastic leukemia (T-ALL). To make the effects more lasting, researchers from St. Jude Children's Research Hospital and the University of Pennsylvania designed proteolysis targeting chimeras (PROTACs) using dasatinib as an LCK ligand and phenyl-glutarimide as a cereblon-directing moiety.
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Cancer

University of Michigan divulges new PROTACs for cancer

Sep. 30, 2022
University of Michigan has described new proteolysis targeting chimeric (PROTACs) compounds comprising cereblon (CRBN) ligands covalently bonded to CREB-binding protein (CBP) and/or histone acetyltransferase KAT3B (p300)-targeting moiety through linker reported to be useful for the treatment of cancer.
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Cancer cell
Cancer

Arginase inhibitor OATD-02 shows promise in cancer treatment

Sep. 15, 2022
Arginases play key roles in metabolic pathways. Arginase 1 (ARG1) is expressed by myeloid cells in the tumor microenvironment and suppresses the functioning of T and NK cells.
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Patient death leads to a partial clinical hold for Curis

April 4, 2022
By Lee Landenberger
A patient’s death has prompted the FDA to place a partial clinical hold on Curis Inc.’s phase I/IIa study of emavusertib in leukemia. The patient, who had relapsed or refractory acute myeloid leukemia, experienced several conditions. One of them was rhabdomyolysis, a dose-limiting toxicity of emavusertib. Rhabdomyolysis is a breakdown of muscle fibers in the blood.
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Bill Ludwig and Carl June

Cancer therapy pioneer calls CAR T ‘cure’

Feb. 3, 2022
By Nuala Moran
LONDON – “I really believe we can start using the word cure,” said the pioneer of chimeric antigen receptor T-cell (CAR T) therapy Carl June, as he revealed two leukemia patients he treated in a phase I trial have now been in remission for 10 years. Both patients with chronic lymphocytic leukemia achieved complete remission shortly after treatment in 2010. The genetic modification has remained detectable in their CAR T cells for more than 10 years of follow-up, June said, describing details of the case studies published in Nature Feb. 2.
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Bill Ludwig and Carl June

Cancer therapy pioneer calls CAR T ‘cure’

Feb. 2, 2022
By Nuala Moran
LONDON – “I really believe we can start using the word cure,” said the pioneer of chimeric antigen receptor T-cell (CAR T) therapy Carl June, as he revealed two leukemia patients he treated in a phase I trial have now been in remission for 10 years. Both patients with chronic lymphocytic leukemia achieved complete remission shortly after treatment in 2010. The genetic modification has remained detectable in their CAR T cells for more than 10 years of follow-up, June said, describing details of the case studies published in Nature Feb. 2.
Read More
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