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Home » non-small-cell lung cancer

Articles Tagged with ''non-small-cell lung cancer''

Lung cancer illustration
Cancer

STX-721 shows efficacy and selectivity in EGFR exon 20 mutant models

Nov. 9, 2022
Researchers from Scorpion Therapeutics Inc. presented preclinical data for the novel EGFR exon 20 mutant inhibitor STX-721, being developed for the treatment of non-small-cell lung cancer (NSCLC).
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Cancer

Mirati Therapeutics discovers new KRAS G12C inhibitors for NSCLC

Nov. 8, 2022
Mirati Therapeutics Inc. has described GTPase KRAS (G12C mutant) inhibitors reported to be useful for the treatment of cancer, in particular non-small-cell lung cancer (NSCLC).
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Cancer

Navrogen enters CRADA with NCI to study anti-mesothelin ADC NAV-001 in clinic

Nov. 8, 2022
Navrogen Inc. has entered into a cooperative research and development agreement (CRADA) with researchers at the U.S. National Cancer Institute (NCI), part of the National Institutes of Health (NIH). Under this CRADA, Navrogen will sponsor the clinical investigation of the experimental antibody-drug conjugate (ADC) NAV-001, under supervision of the NCI.
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CAB taxis to phase II lung win for Bioatla; AXL path greased?

Nov. 4, 2022
By Randy Osborne
Given Bioatla Inc.’s positive update from the study testing mecbotamab vedotin (BA-3011) in metastatic non-small-cell lung cancer sharpened investor thirst for more data by the end of this year, and Wall Street wanted to know how good the findings need to be in order to advance further.
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Lung cancer illustration
Cancer

HER2 exon 20 mutation inhibitor shows promise for the treatment of NSCLC

Nov. 4, 2022
Approximately 1-3% of non-small-cell lung cancer (NSCLC) patients present HER2 exon 20 insertion (exon20ins) mutations.
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Lung cancer illustration
Cancer

Preclinical characterization of BAY-2927088 in models of EGFR mutant NSCLC

Oct. 31, 2022
Researchers from Bayer AG presented the discovery of BAY-2927088, a new noncovalent tyrosine kinase inhibitor targeting EGFR exon 20 insertions and C797S resistance mutations in non-small-cell lung cancer (NSCLC).
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Lung cancer illustration
Cancer

Prelude receives clearance for phase I study of SMARCA2 protein degrader PRT-3789 for solid tumors

Oct. 19, 2022
Prelude Therapeutics Inc. has received...
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Cancer

Biomea Fusion allowed to begin clinical trial of BMF-219 in KRAS-mutant solid tumors

Oct. 17, 2022
Biomea Fusion Inc. has received IND clearance from the FDA to begin a phase I/Ib trial of BMF-219, a selective, covalent menin inhibitor in patients with unresectable, locally advanced, or metastatic non-small-cell lung cancer (NSCLC), colorectal cancer, or pancreatic ductal adenocarcinoma with an activating KRAS mutation.
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Metastatic melanoma cells.
Immuno-oncology

Lyell receives IND clearance for phase I trial of TIL therapy LYL-845 for melanoma and solid tumors

Oct. 7, 2022
Lyell Immunopharma Inc. has received FDA clearance for its IND application to initiate a phase I trial for LYL-845, an investigational tumor-infiltrating lymphocyte (TIL) therapy enhanced with Lyell's Epi-R technology for patients with relapsed and/or refractory metastatic or locally advanced melanoma and other select solid tumors.
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Cancer

New EGFR-mutant inhibitors discovered at Blueprint Medicines

Oct. 6, 2022
Blueprint Medicines Corp. has divulged new EGFR mutant inhibitors, particularly EGFR L858R mutant and EGFR del746-750 mutant, reported to be useful for the treatment of non-small-cell lung cancer.
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