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Home » acute myeloid leukemia

Articles Tagged with ''acute myeloid leukemia''

Long path finally leads to US approval of Daiichi Sankyo’s quizartinib in AML

July 21, 2023
By Jennifer Boggs
Nearly five years after submitting its first NDA seeking U.S. approval for Vanflyta (quizartinib) for treating a subset of patients with acute myeloid leukemia (AML), Daiichi Sankyo Co. Ltd. finally cleared the last hurdle. The FDA on July 20 approved the FLT3 inhibitor for use in combination with cytarabine and anthracycline induction and cytarabine consolidation, and as maintenance monotherapy following consolidation chemotherapy, for the treatment of adult patients with newly diagnosed disease that is FLT3 ITD-positive.
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Immuno-oncology

BVX-001 induces significant tumor regressions in a large tumor murine model of AML

July 18, 2023
Bivictrix Therapeutics plc has released promising final data from a second in vivo efficacy study of its lead clinical candidate BVX-001, a first-in-class Bi-Cygni antibody-drug conjugate (ADC) for the treatment of acute myeloid leukemia (AML).
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Curis emerges from a partial clinical hold and raises $15M

July 6, 2023
By Lee Landenberger
The U.S. FDA has removed the partial clinical hold it placed in April 2022, prompted by a patient’s death, on Curis Inc.’s phase I/IIa study of emavusertib in treating leukemia. The company also said it just raised $15 million to keep everything going.
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Acute myeloid leukemia
Cancer

Foxy-5 as an antineoplastic agent with efficacy in models of AML

July 6, 2023
It has been previously demonstrated that the WNT gene/protein family member WNT5A is down-regulated in leukemia, and low expression of this tumor suppressor has been correlated with disease progression and poor prognosis. In a recent study, researchers from Universidade Estadual de Campina aimed to assess the role of WNT5A in leukemia and evaluate the effects of Foxy-5, (Wntresearch AB) a WNT5A-mimicking compound, on the progression of this disease.
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Acute myeloid leukemia
Cancer

LT-540-717, a novel FLT3 inhibitor with promising efficacy in models of FLT3-mutant AML

July 4, 2023
Researchers from China Pharmaceutical University have reported the discovery of novel orally bioavailable fms-like tyrosine kinase 3 (FLT3) inhibitors as potential candidates for the treatment of acute myeloid leukemia (AML). Synthesis and optimization of a novel series of FLT3 inhibitors led to the identification of LT-540-717 as the lead candidate.
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Mendus to evaluate vididencel-oral-aza combo as maintenance therapy in AML

June 27, 2023
By Cormac Sheridan
Later this year, Mendus AB plans to move its allogeneic cell-based cancer vaccine, vididencel, into a phase II combination trial with oral azacitidine to evaluate the regimen’s potential as a maintenance therapy in patients with acute myeloid leukemia (AML).
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Immune

Prime Medicine and Cimeio collaborate to improve HSC transplants for genetic diseases, AML and MDS

June 23, 2023
Prime Medicine Inc. and Cimeio Therapeutics Inc. have entered into a research collaboration to combine their respective technologies.
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Cancer

Chia Tai Tianqing Pharmaceutical describes new BTK degradation inducers

June 13, 2023
Chia Tai Tianqing Pharmaceutical Group Co. Ltd. has identified proteolysis targeting chimeras (PROTACs) comprising cereblon (CRBN) ligands coupled to a Bruton tyrosine kinase (BTK) targeting moiety via linker and thus acting as BTK degradation inducers.
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Immuno-oncology

EHA 2023: IF they work, logic-gated CAR T cells could work BETTER for complex targeting

June 13, 2023
By Anette Breindl
Part of the reason for CAR T cells’ astonishing success in B-cell cancers is that B cells are astonishingly easy to replace. CAR T cells are specific, yes. But they are not specific to tumor cells. They are specific to their target antigens. In the case of Yescarta (axicabtagene ciloleucel, Gilead Sciences Inc.) and Kymriah (tisagenlecleucel, Novartis AG), the first two clinically approved T cells, that target is CD19, which is expressed on B-cell precursors. And when it is successful, the treatment leaves patients without any B cells at all.
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Acute myeloid leukemia
Immuno-oncology

Bivictrix Therapeutics nominates clinical candidate for lead BVX-001 program

June 7, 2023
Bivictrix Therapeutics plc has nominated a clinical candidate for its lead BVX-001 program, following promising in vivo efficacy data.
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