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Home » melanoma

Articles Tagged with ''melanoma''

Cancer

TP-317 enhances efficacy of immune checkpoint inhibitor therapy in cancer, study demonstrates

April 18, 2023
Thetis Pharmaceuticals LLC and Harvard Medical School have presented data on the stable salt chelate of Resolvin E1, TP-317, for the potential treatment of immune checkpoint inhibitor (ICI)-resistant and sensitive tumors. TP-315 is an activator of ChemR23, a receptor expressed on immune cells in the tumor microenvironment. In vivo murine models of lung, melanoma (B16F10) and pancreatic (Panc2-H7) tumors were used to investigate TP-317 monotherapy and in combination with ICI.
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Cancer

NR2F2 isoform pushes melanoma into metastatic form

April 14, 2023
It is known that in melanoma, transformed melanocytic cells acquire stem cell-like features; these cells have multilineage differentiation potential, thus allowing them to morph into cell states with neural crest cell (NCC)-like, epithelial-to-mesenchymal transition-like features, promoting its metastatic potential.
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Metastatic melanoma cells.
Cancer

MAPKAP1 as new therapeutic target in treatment-resistant melanoma

March 14, 2023
The mTORC2 complex plays an important role in the PI3K/AKT/mTOR pathway, allowing activation of AKT and contributing to the development of BRAF-mutated (BRAFm) melanomas and their resistance to treatments. Researchers from Inserm aimed to identify new candidates for targeting the mTORC2 complex in melanoma, with focus on one principal protein of this complex, MAPKAP1 (also known as SIN1).
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Melanoma cells stained with an H & E stain and magnified to 320x.
Cancer

BAY-293 shows synergy with MAP kinase pathway inhibitors in human melanoma cell lines

March 9, 2023
Researchers from Medical University Vienna presented data from a study that aimed to identify possible synergism between the novel son of sevenless (SOS) inhibitor BAY-293 and B-Raf or/and MEK1/2 inhibitors as a potential therapeutic strategy for the treatment of melanoma.
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Immuno-oncology

Ocean Biomedical studies bispecific antibodies targeting CHI3L1 and PD-1 or CTLA-4 in experimental models

Feb. 24, 2023
Ocean Biomedical Inc. has discovered bispecific antibodies that target Chitinase 3-like-1 (CHI3L1) and immune checkpoint inhibitors, killing glioblastoma cells and melanoma cells, and blocking the metastasis of malignant melanoma cells to the lung by over 90%.
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Melanoma cells stained with an H & E stain and magnified to 320x.
Cancer

New iridium(III) complexes show efficacy in preclinical models of cancer

Feb. 20, 2023
Researchers from Guangdong Pharmaceutical University presented the discovery of novel iridium(III) complexes as potential anticancer agents.
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Antibodies attacking cancer cell
Immuno-oncology

Atreca and Xencor select first collaborative program combining Atreca antibodies and Xencor CD3 bispecific engineering

Feb. 7, 2023
Atreca Inc. and Xencor Inc. have mutually selected the first program from their strategic collaboration combining an Atreca-discovered antibody with Xencor's Xmab bispecific Fc domain and a cytotoxic T-cell binding domain (CD3).
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Immuno-oncology

Transcode reports preclinical proof-of-mechanism study results with immunotherapy TTX-RIGA

Feb. 1, 2023
Transcode Therapeutics Inc. has conducted...
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Neutrophil and red blood cells
Cancer

Redeeming neutrophils could be anticancer approach

Jan. 27, 2023
By Mar de Miguel
Unexpected behavior of neutrophils unveiled by researchers at Stanford University could lead to a new type of immunotherapy to treat cancer. Although various studies have suggested that these cells are harmful due to their immunosuppressive characteristics, the scientists saw in them an opportunity to redirect them and eliminate tumors.
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Iovance ‘leukin good after Clinigen transaction as lifileucel BLA stays the course

Jan. 25, 2023
By Randy Osborne
Iovance Biotherapeutics Inc.’s faith in tumor-infiltrating lymphocyte (TIL) therapy lifileucel was further proven by the Jan. 23 acquisition of worldwide rights from Clinigen Ltd. to Proleukin (aldesleukin), an IL-2 product used to promote T-cell activity after infusion of TILs. Terms call for San Carlos, Calif.-based Iovance to pay Clinigen, of Burton Upon Kent, U.K., £166.7 million (US$$206.1 million) right away and a £41.7 million milestone payment upon first approval of lifileucel in advanced melanoma, plus double-digit global royalties for Clinigen.
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