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Home » ovarian cancer

Articles Tagged with ''ovarian cancer''

3D illustration of tumor
Immuno-oncology

Harbour Biomed’s ADC HBM-9033 receives FDA clearance to enter clinic for advanced solid tumors

Aug. 28, 2023
Harbour Biomed Ltd. has received FDA clearance of its IND application to commence a phase I trial of HBM-9033 in advanced solid tumors. Developed in collaboration with Medilink Therapeutics (Suzhou) Co. Ltd., HBM-9033 is an antibody-drug conjugate that specifically targets human mesothelin (MSLN), an upregulated tumor-associated antigen in various solid tumors, including mesothelioma, ovarian cancer, lung cancer, breast cancer and pancreatic cancers. The fully human monoclonal antibody in HBM-9033, generated from the Harbour Mice platform, binds preferably to membrane bond MSLN over soluble MSLN, which minimizes the interference of the shedding MSLN on the binding and internalization of the membrane bond MSLN.
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Antibodies attacking cancer cell
Immuno-oncology

Novarock's bispecific antibody NBL-028 cleared to enter clinic for CLDN6-expressing tumors

Aug. 18, 2023
Novarock Biotherapeutics Ltd., a subsidiary of CSPC Pharmaceutical Group Ltd., has received FDA approval of its IND application for NBL-028, a CLDN6-CD137 bispecific antibody.
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Cancer

Prelude Therapeutics discovers new CDK inhibitors for cancer

Aug. 17, 2023
Prelude Therapeutics Inc. has described cyclin dependent kinase (CDK) inhibitors reported to be useful for the treatment of cancer.
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Antibody-drug conjugate illustration
Immuno-oncology

Oncusp's CDH6-targeting ADC CUSP-06 cleared to enter clinic for solid tumors

Aug. 17, 2023
Oncusp Therapeutics Inc. has received IND clearance from the FDA to begin clinical trials with CUSP-06, a cadherin-6 (CDH6)-targeting antibody-drug conjugate designed for the treatment of multiple solid tumors. CDH6 is overexpressed in cancers including ovarian, renal, uterine, thyroid, lung, and cholangiocarcinoma. A phase I trial will pave the way for expansion in patients with platinum-refractory/resistant ovarian cancer and other advanced solid tumors.
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Cancer

Biomarker discovery for patients with treatment-resistant ovarian cancer

Aug. 7, 2023
Despite continual investment in research focused on high-grade serous ovarian cancer (HGSOC), the 5-year survival rate of ∼30% for most patients has remained unchanged for decades. While ≤20% of HGSOC patients present with treatment-refractory disease, therapeutic strategies have not changed outcomes for these patients in 40 years.
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3d illustration of ovarian cancer

Aravive misses a phase III primary endpoint and faces tough decisions on two other studies

Aug. 3, 2023
By Lee Landenberger
Aravive Inc.’s sole asset missed a phase III primary endpoint in ovarian cancer but the company still has studies planned for treating renal cell carcinoma and pancreatic cancer. Aravive’s stock (NASDAQ:ARAV) dwindled dramatically on Aug. 3, with shares closing 77.2% lower at 28 cents each. That’s a massive drop from heights seen in the past 12 months, as shares hit $2.46 each in March 2023 and $2.09 each in November 2022. The company plans to study the data and make a decision about whether to proceed with the other studies.
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Ovarian cancer illustration

Mersana’s Uplift falls down in prOC; shares follow

July 27, 2023
By Randy Osborne
Mersana Therapeutics Inc. followed grim June news with an even worse headline as the phase Ib/II study called Uplift with upifitamab rilsodotin (upri) did not meet its primary endpoint in platinum-resistant ovarian cancer (prOC). The antibody-drug conjugate (ADC) targets the sodium-dependent phosphate transport protein NaPi2b and was developed via the company’s platform called Dolaflexin. Shares of Mersana (NASDAQ:MRSN) tumbled 73%, or $2.84, to close July 27 at $1.07 on word of the failure of the trial.
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Tumor microenvironment
Cancer

Circle Pharma selects dual cyclin A/B inhibitor as clinical candidate

July 20, 2023
Circle Pharma Inc. has selected CID-078 as its first clinical development candidate. CID-078 is an orally bioavailable macrocycle with dual cyclin A and B inhibitory activity that drives synthetic lethality in multiple tumor types.
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3D illustration demonstrating antibody-drug conjugate.
Immuno-oncology

Preclinical characterization of B7-H4 antibody-drug conjugate XMT-1660

July 7, 2023
B7-H4 is an immune-suppressive protein overexpressed in several tumors, including breast, endometrial and ovarian cancers, that has been successfully targeted with antibody-drug conjugate (ADC) strategies in preclinical testing.
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Microenvironment of a HER2-expressing breast tumor
Immuno-oncology

Hillstream licenses technology from ABSI for antibodies targeting novel HER2 and HER3 conformational epitopes

July 7, 2023
Hillstream Biopharma Inc. has signed an exclusive agreement with Applied Biomedical Science Institute (ABSI) to license technology for human antibodies targeting novel HER2 and HER3 conformational epitopes. The goal is to develop proprietary multiformat biologics, including bispecific antibodies and antibody-drug conjugates (ADCs).
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