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Home » ovarian cancer

Articles Tagged with ''ovarian cancer''

Cancer

GP-2250 exerts antitumoral effects by impacting tumor metabolism

Aug. 16, 2024
Researchers have developed and tested a taurultam-derived oxathiazine compound, GP-2250, for the potential treatment of ovarian cancer. Taurolidine, a substance derived from the amino acid taurine, has been shown to have antiproliferative and antineoplastic activity in vitro and in vivo against various cancer types. GP-2250 was tested in vitro in several ovarian cancer cell lines, as well as in vivo as a monotherapy and in combination with standard-of-care drugs and PARP inhibitors.
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Ovarian cancer gene therapy shows promise; Imunon preps for phase III

July 30, 2024
By Karen Carey
Phase II data showing an 11.1-month improvement in overall survival for advanced ovarian cancer patients treated with the IL-12 immunotherapy IMNN-001 drove up shares of Imunon Inc. by 181% July 30. The results “could usher in the first immune-based therapy for ovarian cancer,” said Stacy Lindborg, president and CEO of the Lawrenceville, N.J.-based company.
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Cancer

Novel RNP13 inhibitor shows synergy with cisplatin in ovarian tumor models

July 24, 2024
Proteasome inhibitors such as bortezomib have shown promise in ovarian cancer treatment but limitations like route of administration or severe side effects restrict their use. Targeting proteasomal ubiquitin receptor ADRM1, also known as RPN13, has emerged as an alternative strategy and some RPN13 inhibitors are in early development.
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Illustration of a cluster of ovarian cancer cells
Cancer

Cancer cells adapt to resist therapy step by step

July 23, 2024
By Mar de Miguel
The adaptation of cancer cells to therapies limits the effectiveness of treatments. However, understanding the mechanisms they use to do it could help reverse them or be used to design more powerful drugs. Scientists at New York University (NYU) have studied the transitions causing resistance and have observed how it develops through a gradual process they have called the “resistance continuum.”
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3D illustration demonstrating antibody-drug conjugate.
Immuno-oncology

Zymeworks obtains IND clearance for FRα-targeted ADC

July 22, 2024
Zymeworks Inc. has received IND clearance from the FDA for ZW-191, the company’s novel folate receptor-α (FRα)-targeted topoisomerase I (TOPO1) inhibitor antibody-drug conjugate (ADC). Clinical development is set to begin this year, with filings to initiate studies outside the U.S. to be made in the second half of this year.
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Cancer

Shenzhen Bay Laboratory describes new USP1 inhibitors

July 17, 2024
Shenzhen Bay Laboratory has identified ubiquitin carboxyl-terminal hydrolase 1 (USP1) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Chinese researchers divulge new KIF18A inhibitors

July 16, 2024
Scientists at Shanghai Aryl Pharmtech Co. Ltd. and Zhejiang Hisun Pharmaceutical Co. Ltd. have synthesized kinesin-like protein KIF18A inhibitors reported to be useful for the treatment of cancer.
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Illustration of female reproduction system
Biomarkers

Genetic variation in GEN1 predicts poor survival in epithelial ovarian cancer

July 9, 2024
Epithelial ovarian cancer (EOC) is the most predominant histologic type of ovarian cancer, with about 55% of patients at an advanced stage when diagnosed; overall survival remains poor.
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Eisai forging ahead after Bristol Myers drops out of ADC deal

July 2, 2024
By Jennifer Boggs
At a time when much of the biopharma space can’t seem to get enough of antibody-drug conjugates (ADC), Bristol Myers Squibb Co. is backing away from a potential $3 billion-plus collaboration with Eisai Co. Ltd., handing back full rights to the latter’s folate receptor alpha-targeting ADC, farletuzumab ecteribulin (FZEC), citing a portfolio reprioritization.
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Eisai forging ahead after Bristol Myers drops out of ADC deal

July 1, 2024
By Jennifer Boggs
At a time when much of the biopharma space can’t seem to get enough of antibody-drug conjugates (ADC), Bristol Myers Squibb Co. is backing away from a potential $3 billion-plus collaboration with Eisai Co. Ltd., handing back full rights to the latter’s folate receptor alpha-targeting ADC, farletuzumab ecteribulin (FZEC), citing a portfolio reprioritization. Global rights to FZEC now reside with Tokyo-based Eisai, which said it intends to accelerate work on the candidate, which is in three clinical studies, including two phase II trials in gynecological cancers and non-small-cell lung cancer.
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