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Home » tau

Articles Tagged with ''tau''

Tau neuron illustration

LDL receptor overexpression affects tauopathy in Alzheimer's model

June 29, 2021
By W. Todd Penberthy
Researchers report in the June 21, 2021, online issue of Neuron that overexpression of the LDL receptor can reduce ApoE to prevent tauopathy-associated neurodegeneration in mouse models.
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Tau neuron illustration

Alzheimer's vaccine advances with positive interim data

Feb. 11, 2021
By Michael Fitzhugh
Nearly five months after its tau-directed antibody, semorinemab, failed to demonstrate efficacy in a phase II trial in Alzheimer’s disease, AC Immune SA is back with positive data on a different approach with its anti-phospho-tau vaccine candidate, ACI-35.030.
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Tau neuron illustration

AC Immune shares tumble as semorinemab fails to validate tau hypothesis in Alzheimer’s

Sep. 23, 2020
By Cormac Sheridan
DUBLIN – Shares in AC Immune SA were off more than 40% Sept. 23 on news that its tau-directed antibody, semorinemab, which is partnered with Genentech, failed to demonstrate efficacy in a phase II trial in Alzheimer’s disease.
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Journey over

Abbvie drops options of Voyager's Alzheimer's, Parkinson's programs

Aug. 4, 2020
By Michael Fitzhugh
Bold up-fronts and even bigger milestones defined ambitious neurology deals Abbvie Inc. struck with Voyager Therapeutics Inc. in 2018 and 2019. With vectorized antibodies, they planned to target multiple indications tied to excess aggregations of tau and tragic synucleinopathies. Considerable progress was made, said Omar Khwaja, Voyager's chief medical officer. But despite millions of dollars invested in the programs, Abbvie has now decided to quit the venture, leaving Voyager to either go it alone or find a new partner in its work on the challenging indications.
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Tau neuron illustration

Roche seeks potential Alzheimer’s treatment in UCB anti-tau drug with $2B+ licensing deal

July 29, 2020
By Michael Fitzhugh
UCB SA, a Belgian company developing an antibody targeting a toxic protein tied to Alzheimer’s disease (AD), said Roche Holding AG has negotiated an exclusive global license to the potential therapy for $120 million up front, plus almost $2 billion in milestone payments following positive proof of concept for the anti-tau candidate, UCB-0107, in AD.
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Tau neuron illustration
Tautism?

Tau protein plays role in autism spectrum disorder

March 4, 2020
By Anette Breindl
Lowering levels of tau protein improved multiple symptoms of autism spectrum disorders (ASD) in two different mouse models of the disease, both of which are driven by hyperactivity of the mTOR PI3 kinase pathway.
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Tau neuron illustration
Tautism?

Tau protein plays role in autism spectrum disorder

March 2, 2020
By Anette Breindl
Lowering levels of tau protein improved multiple symptoms of autism spectrum disorders (ASD) in two different mouse models of the disease, both of which are driven by hyperactivity of the mTOR PI3 kinase pathway.
Read More

With positive early results, team moves forward on Alzheimer's vaccine

July 1, 2019
By Sergio Held
A research team at the University of New Mexico (UNM), Albuquerque, is moving forward with the development of a vaccine against tauopathies, a neurodegenerative class of diseases that includes Alzheimer's disease, but while promising in the lab, it could take a decade to get an actual vaccine to market.
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