Isoniazid is a first-line medicine for tuberculosis (TB) treatment. It is a prodrug activated by the mycobacterial catalase-peroxidase enzyme KatG. However, the development of isoniazid resistance compromises treatment efficacy and contributes to multidrug-resistant TB infections.
Investigators from Microbiotix Inc. have published preclinical data for the novel spectinamide, MBX-4888A (Lee-1810), being developed for the treatment of tuberculosis (TB).
Having secured a 40% price cut and a commitment to not enforce a patent protecting a tuberculosis drug, South Africa’s Competition Commission decided not to prosecute a complaint accusing Johnson & Johnson (J&J) and its subsidiary, Janssen Pharmaceutica (Pty) Ltd., of anticompetitive conduct.
Noze Inc. is hot on the trail of tuberculosis with its Diagnoze hand-held system that can detect the disease by its smell. The company, formerly known as Stratuscent, received additional support from the Bill & Melinda Gates Foundation to fund a study evaluating a breathalyzer designed to detect tuberculosis in high-burden countries.
Researchers from the University of Stellenbosch in South Africa are seeking protection for a simple and user-friendly point-of-care device for diagnosing tuberculosis. Their electrochemical lateral flow device merges lateral flow device technology and electrochemical device technology by using porous electrodes that are capable of transporting electrolytic liquid and fluid sample.
Cukurova University and the University of Alicante have synthesized new 2-(pyrrolidin-1-yl)thiazole compounds reported to be useful for the treatment of bacterial infections and tuberculosis.
The current standard treatment for tuberculosis (TB) consists of a combination of four antibiotics administered for 6 to 12 months. There is hence a clear need for new strategies both for shorter treatment periods and that may address the emergence of multi- and extensive drug-resistant TB. Researchers from Scripps Research Institute have reported on the synthesis and preclinical characterization of a series of novel aryl fluorosulfate derivatives designed to be used for the treatment of TB.
Proteinlogic Ltd. and Stellenbosch University have received a $1.35 million grant from the Bill & Melinda Gates Foundation to develop a blood test to monitor treatment responses to tuberculosis (TB) antimicrobial chemotherapy.
Benzothiozinone (BTZ) compounds are among the new entities under development for their antimycobacterial activity, but information on their efficacy in acute tuberculosis (TB) infection models is still lacking.
The Novo Nordisk Foundation is committing up to DKK1.8 billion (US$260 million) to establish a research and vaccine development initiative that aims to create new or improved vaccines for respiratory diseases, including tuberculosis (TB) and influenza.
