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Home » APOE

Articles Tagged with ''APOE''

Brain-DNA illustration

Astrocytic ApoE mediates memory consolidation in mice

Jan. 28, 2021
By John Fox
A study led by scientists at the University of Science and Technology of China in Hefei City is the first to show that astrocytic apolipoprotein E (ApoE) regulates neuronal epigenetic states via reprogramming lipid metabolism, which was shown to control brain function, in particular memory consolidation, in mice.
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Immune cell density plot
Reversal of ApoE4tune

Germline ApoE variants affect melanoma trajectory

May 27, 2020
By Anette Breindl
Variants in the APOE gene are the strongest genetic risk factor for developing Alzheimer’s disease (AD). Now, researchers at Rockefeller University have demonstrated that APOE variants also affected the risk of progression and metastasis as well as the response to immunotherapy, in melanoma.
Read More
Immune cell density plot
Reversal of ApoE4tune

Germline ApoE variants affect melanoma trajectory

May 26, 2020
By Anette Breindl
Variants in the APOE gene are the strongest genetic risk factor for developing Alzheimer’s disease (AD). Now, researchers at Rockefeller University have demonstrated that APOE variants also affected the risk of progression and metastasis as well as the response to immunotherapy, in melanoma.
Read More
Illustration of children with different skin tones
Snow White and the Seven snow white genomes

Lack of genomic diversity means actionable mutations are left undiscovered

Dec. 31, 2019
By Anette Breindl
Genome sequencing is enabling new insights into the genetic aspects of health and disease that have touched just about every aspect in biomedicine. It is also, like the “skin”-colored crayons of yore, disproportionately focused on the Caucasian segment of the population. And that is a loss for everyone.
Read More
children-skin-tones-12-31.png
Snow White and the seven snow white genomes

Lack of genomic diversity means actionable mutations are left undiscovered

Dec. 31, 2019
By Anette Breindl
Genome sequencing is enabling new insights into the genetic aspects of health and disease that have touched just about every aspect in biomedicine. It is also, like the “skin”-colored crayons of yore, disproportionately focused on the Caucasian segment of the population. And that is a loss for everyone.
Read More
DNA illustration
APOE has secrets left

Large datasets, good statistics allow disease-agnostic SNP discoveries

Dec. 24, 2019
By Nuala Moran
LONDON – While large-scale biobanks that link genomics to longitudinal health records of diagnosis, treatment and outcomes promise to revolutionize the understanding of the genetics of complex disease, the detailed statistical analysis of those high-dimensional data is still very much in its infancy.
Read More
APOE has secrets left

Large datasets, good statistics allow disease-agnostic SNP discoveries

Dec. 23, 2019
By Nuala Moran
LONDON – While large-scale biobanks that link genomics to longitudinal health records of diagnosis, treatment and outcomes promise to revolutionize understanding of the genetics of complex disease, the detailed statistical analysis of those high-dimensional data is still very much in its infancy.
Read More
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