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Home » EGFR

Articles Tagged with ''EGFR''

Cancer

Beigene divulges new EGFR mutant-targeting PROTACs for cancer

Nov. 25, 2022
Beigene Co. Ltd. has synthesized proteolysis targeting chimera (PROTAC) compounds comprising a cereblon (CRBN) E3 ubiquitin ligase-binding moiety covalently linked to an EGFR (mutant)-targeting moiety via linker.
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T cells
Immuno-oncology

Seagen and Lava enter license agreement for γδ bispecific T-cell engager LAVA-1223

Sep. 27, 2022
Seagen Inc. and Lava Therapeutics NV have entered into an exclusive license agreement under which Seagen will work to develop, manufacture and commercialize LAVA-1223, a bispecific T-cell engager designed to target and activate Vγ9Vδ2 T cells in the presence of epidermal growth factor receptor (EGFR)-expressing solid tumors.
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T cells

Lava soars on $700M Seagen deal for EGFR Gammabody candidate

Sep. 26, 2022
By Jennifer Boggs
Shares of Lava Therapeutics NV rocketed by more than 90% Sept. 26 as the company disclosed a licensing deal with Seagen Inc. to develop and commercialize preclinical-stage EGFR-targeting bispecific candidate LAVA-1223, which comes with $50 million in up-front funding and up to a potential $650 million in milestones. It also adds further validation for harnessing gamma-delta T cells to treat cancer, an approach that is growing increasingly popular.
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Microscopic image of the blood-brain barrier in a mouse.
Cancer

Preclinical activity described for Erasca's blood-brain barrier-penetrant EGFR inhibitor for glioblastoma

Sep. 16, 2022
Epidermal growth factor receptor (EGFR) is a target in many cancers, but EGFR inhibitors have displayed little utility in treating glioblastoma (GBM) due to limited blood-brain barrier (BBB) penetration.
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ESMO 2022

Study gives new insights into pollution, inflammation, cancer initiation

Sep. 12, 2022
By Anette Breindl
“The association between air pollution and lung cancer is not new,” Charles Swanton told the audience at the European Society of Medical Oncology (ESMO) 2022 Congress. But as with so many associations, causation has been hard to establish, partly due to the puzzling absence of mutations.
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Digital lungs illustration

Blueprint as Pioneer learning the ‘Lengo,’ speaks to hopeful market in EGFR exon 20 NSCLC

Aug. 4, 2022
By Randy Osborne
With data due later this summer from the phase II Pioneer trial testing Blueprint Medicines Corp.’s approved Ayvakit (avapritinib), many investor eyes are on the potential label expansion into indolent systemic mastocytosis – but the company has another potential ace in the hole with BLU-451, which targets EGFR exon 20 insertion mutations in non-small-cell lung cancer (NSCLC).
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Lung cancer illustration

Acea Pharma fails to win green light for abivertinib in China

May 24, 2022
By Doris Yu
Zhejiang Acea Pharmaceutical Co. Ltd. failed to obtain marketing approval from China’s NMPA for its third-generation EGFR tyrosine kinase inhibitor, abivertinib. The NDA was based on a phase II trial of abivertinib in patients with EGFR Thr790Met point mutation-positive non-small-cell lung cancer with disease progression from prior EGFR inhibitors.
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Lung cancer illustration

Acea Pharma fails to win green light for abivertinib in China

May 20, 2022
By Doris Yu
Zhejiang Acea Pharmaceutical Co. Ltd. failed to obtain marketing approval from China’s NMPA for its third-generation EGFR tyrosine kinase inhibitor, abivertinib. The NDA was based on a phase II trial of abivertinib in patients with EGFR Thr790Met point mutation-positive non-small-cell lung cancer with disease progression from prior EGFR inhibitors.
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Concept of business partnership

Taiho goes Pearl diving, brings up $405M Cullinan deal

May 17, 2022
By Randy Osborne
Cullinan Oncology Inc.’s lead program deal with Otsuka Holdings Co. Ltd. subsidiary Taiho Pharmaceutical Co. Ltd. brings $275 million up front and the potential for as much as $130 million in regulatory milestone payments.
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Taiho goes Pearl diving, brings up $405M Cullinan deal

May 12, 2022
By Randy Osborne
Cullinan Oncology Inc.’s lead program deal with Otsuka Holdings Co. Ltd. subsidiary Taiho Pharmaceutical Co. Ltd. brings $275 million up front and the potential for as much as $130 million in regulatory milestone payments.
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