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Home » T cells

Articles Tagged with ''T cells''

Natural killer cell
ESMO TAT

Heating cold tumors one subtype, and one cell type, at a time

March 8, 2022
By Anette Breindl
“In 2015, when I started in this field…. people considered breast cancer a cold tumor,” Marleen Kok told the audience at the European Society of Medical Oncology’s 2022 Targeted Anticancer Therapy meeting (ESMO TAT). But the sensitivity of breast cancer to immunotherapy, or lack thereof, is “not a black and white phenomenon.”
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Marker’s phase II data and pipeline expansion prompt market wobble

Feb. 17, 2022
By Lee Landenberger
Marker Therapeutics Inc.’s update from the safety lead-in stage of its phase II study of MT-401 in treating post-transplant acute myeloid leukemia saw response in one of the six participants. The results from the study of the multitumor-associated antigen-specific T-cell product also known as zelenoleucel saw firms such as Oppenheimer cut its target price for Marker to $5 from $8 and Piper Sandler to cut its target price from $5.50 to $4.
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Microscope image of SARS-CoV-2

T-cell evasion is one pressure shaping SARS-CoV-2 evolution

Feb. 14, 2022
By Nuala Moran
The overwhelming focus of research into the cellular immune response to SARS-CoV-2 has been investigating the reaction of vaccinated people, in an effort to establish correlates of protection required to fight off infection. But with a majority in many African and Asian countries still unvaccinated, it also is important to understand the natural cellular immune response, and to track the emergence of SARS-CoV-2 variants with the potential to escape immunity in these populations.
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T cells

Study shows cross-protection of common cold T cells against SARS-CoV-2

Jan. 10, 2022
By Nuala Moran
LONDON – T cells generated as a result of infection with common cold coronaviruses provide cross-protection against being infected with SARS-CoV-2, according to a new study.
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T-cell findings suggest pan-coronavirus vaccine approach for SARS-CoV-2, variants

Nov. 11, 2021
By Nuala Moran
LONDON – Intensive monitoring of health care workers at two hospitals in London showed that despite having a blood biomarker of infection, 58 of them did not test positive for COVID-19 at any point, suggesting they may have been clearing subclinical infections before seroconversion.
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Zhen Su, CEO, Marengo Therapeutics

Marengo closes $80M A round to harness novel antibody-mediated T-cell activation for cancer

Nov. 8, 2021
By Cormac Sheridan
Marengo Therapeutics Inc. is opening up a new front in the war on cancer by selectively deploying a tumor-infiltrating subpopulation of T cells, which can be activated by a newly identified, antibody-based mechanism. The Cambridge, Mass.-based company is taking forward a scientific concept that has been germinating for several years at founding investor and company creator ATP, which has now launched the firm with an $80 million series A round. Marengo is gearing up for a first clinical trial in 2022. “It’s a new chapter in T-cell biology,” CEO Zhen Su told BioWorld.
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CAR T cell attacking cancer cells

With series A backing, Leucid heads for clinic with third-gen CAR T

Oct. 21, 2021
By Richard Staines
There’s a whole group of biotechs trying to create a tougher next-generation CAR T-cell therapy that could have a powerful effect on solid tumors after the technology’s first successes in blood cancer. One of those is London-based Leucid Bio Ltd., which has just raised £11.5 million (nearly US$16 million) in series A financing to develop next-generation CAR T therapies that are able to make it through to solid tumors and attack them.
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T cells

T-cell exhaustion is durable, but specific

Aug. 9, 2021
By Anette Breindl
It's a good news, bad news scenario for exhausted T cells in chronic infections. Multiple groups of investigators reported in the July 26, 2021, online issue of Nature Immunology that even after a chronic hepatitis C virus infection was cured, T cells that had become dysfunctional during the infection retained epigenetic "scars" that prevented them from becoming fully functional memory T cells.
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T cells

T-cell exhaustion is durable, but specific

July 28, 2021
By Anette Breindl
It's a good news, bad news scenario for exhausted T cells in chronic infections. Multiple groups of investigators reported in the July 26, 2021, online issue of Nature Immunology that even after a chronic hepatitis C virus infection was cured, T cells that had become dysfunctional during the infection retained epigenetic "scars" that prevented them from becoming fully functional memory T cells.
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3D Euro symbol

ISA Pharma tackles cancer immunotherapy response rates with €26M financing

July 13, 2021
By Richard Staines
ISA Pharmaceuticals BV has closed a €26 million (US$30.76 million) funding round to advance its cancer immunotherapy product, ISA-101b, in the clinic, as the company aims to tackle the low response rates that hold back this therapeutic approach.
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