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Home » COVID-19

Articles Tagged with ''COVID-19''

Infection

Greek scientists patent new spike glycoprotein/ACE2 interaction inhibitors for SARS-CoV-2

Nov. 15, 2024
A group of researchers have disclosed spike glycoprotein (SARS-CoV-2; COVID-19 virus)/ACE2 interaction inhibitors in a new patent.
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Infection

Westlake Pharmaceutical discloses new Mpro inhibitors

Nov. 8, 2024
Westlake Pharmaceutical (Hangzhou) Co. Ltd. has prepared and tested new 3C-like proteinase (3CLpro; Mpro; nsp5) inhibitors reported to be useful for the treatment of coronavirus acute respiratory syndrome.
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Shionogi finds positive data on ensitrelvir for COVID-19

Nov. 5, 2024
By Marian (YoonJee) Chu
Phase III Scorpio-PEP study results showed Shionogi & Co. Ltd.’s oral antiviral ensitrelvir fumaric acid (Xocova) reduced risk of symptomatic COVID-19 infection in subjects who were exposed to the virus by infected household members.
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Shionogi finds positive data on ensitrelvir for COVID-19

Oct. 30, 2024
By Marian (YoonJee) Chu
Phase III Scorpio-PEP study results showed Shionogi & Co. Ltd.’s oral antiviral ensitrelvir fumaric acid (Xocova) reduced risk of symptomatic COVID-19 infection in subjects who were exposed to the virus by infected household members.
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Blood test for Coccidioidomycosis infection
Infection

Fungal, SARS-CoV-2 coinfection studied in new mouse model

Oct. 30, 2024
One of the challenges associated with COVID-19 has been an increase of secondary infections, including fungal infections. These coinfections can hinder treatment efficacy and increase illness severity.
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FDA pauses Novavax’s flu and COVID-19 combo vaccines

Oct. 16, 2024
By Jennifer Boggs
Shares of Novavax Inc. (NASDAQ:NVAX) dropped nearly 20% Oct. 16 to close at $10.15 after the company reported a serious adverse event had prompted a U.S. FDA clinical hold for its COVID-19-influenza combination and standalone flu vaccine candidates.
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Healgen COVID-Flu OTC test kit

FDA authorizes first home flu and COVID-19 combo test outside EUA

Oct. 8, 2024
By Holland Johnson
The U.S. FDA granted marketing authorization for Healgen Scientific LLC’s Rapid Check COVID-19/Flu A&B antigen test.
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Disintegrating coronavirus
Infection

PKI-179 and MTI-31 identified as potent anti-coronavirus compounds

Oct. 8, 2024
The COVID-19 pandemic pushed the urgency for effective antiviral drugs against coronaviruses. Researchers from Europe conducted machine learning and in vitro validation experiments for the identification of potential antiviral drugs effective against coronaviruses.
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Infection

Tohoku University patents new 3CLpro inhibitors

Oct. 1, 2024
Tohoku University has disclosed 3C-like proteinase (3CLpro; Mpro; nsp5) (SARS-CoV-2; COVID-19 virus) inhibitors reported to be useful for the treatment of viral infections and inflammatory disorders.
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Creative rendition of SARS-CoV-2 virus particles.
Infection

Discovery of macrocyclic 3CLpro inhibitors with improved PK properties

Sep. 30, 2024
In work at Shanghai Curegene Pharmaceutical Co. Ltd., synthesis and optimization of a series of SARS-CoV-2 3CL protease (3CLpro, Mpro) inhibitors led to the identification of compounds [I], [II] and [III] as lead candidates suitable for further evaluation, based on their enzymatic IC50s (14, 12 and 8.6 nM, respectively), cellular EC50s (36, 26 and 52 nM, respectively) and human liver microsome (HLM) stability.
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