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Home » head and neck squamous cell carcinoma

Articles Tagged with ''head and neck squamous cell carcinoma''

3D rendering of an antibody drug conjugate
Immuno-oncology

Innocare’s ICP-B794 gains IND clearance in China

July 4, 2025
No Comments
Innocare Pharma Ltd. has obtained IND approval from China’s National Medical Products Administration (NMPA) to initiate a clinical trial of the B7-H3 targeted antibody-drug conjugate.
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3D representation of tumor
Cancer

Aprea reports preclinical data on WEE1 inhibitor APR-1051 for HPV-positive HNSCC

June 26, 2025
No Comments
Aprea Therapeutics Inc. has announced new preclinical data on APR-1051, the company’s next-generation oral WEE1 inhibitor, in human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC).
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Sore throat illustration
Cancer

Study identifies C16orf74 as prognostic biomarker in head and neck cancer

May 27, 2025
No Comments
Head and neck squamous cell carcinoma (HNSCC), which makes up the majority of head and neck cancers, is an aggressive disease with a poor prognosis despite current multimodal treatments. Its progression is strongly linked to immune evasion and impaired immune signaling, highlighting the urgent need for new diagnostic and prognostic biomarkers to improve patient outcomes.
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Floating antibody drug conjugates
Immuno-oncology

ALX Oncology presents preclinical data, plans for ALX-2004

May 21, 2025
No Comments
ALX Oncology Holdings Inc. is set to begin phase I studies around the middle of this year with ALX-2004, an antibody-drug conjugate (ADC) for the treatment of EGFR-expressing solid tumors, following IND clearance last month.
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Head and neck anatomy

Immutep’s efti shows strong survival data in head and neck cancer

May 6, 2025
By Tamra Sami
No Comments
Immutep Ltd. announced strong median overall survival of 17.6 months in cohort B of the TACTI-003 (Keynote-PNC-34) phase IIb trial that evaluated eftilagimod alfa in combination with Merck & Co.’s Keytruda (pembrolizumab) as first-line therapy in recurrent/metastatic head and neck squamous cell carcinoma in patients with PD-L1 expression below 1.
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Head and neck anatomy

Immutep’s efti shows strong survival data in head and neck cancer

May 5, 2025
By Tamra Sami
No Comments
Immutep Ltd. announced strong median overall survival of 17.6 months in cohort B of the TACTI-003 (Keynote-PNC-34) phase IIb trial that evaluated eftilagimod alfa in combination with Merck & Co.’s Keytruda (pembrolizumab) as first-line therapy in recurrent/metastatic head and neck squamous cell carcinoma in patients with PD-L1 expression below 1.
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Digital handshake
Cancer

MD Anderson to explore Aprea’s WEE1 kinase inhibitor for HNSCC

March 12, 2025
Aprea Therapeutics Inc. has entered into a material transfer agreement with MD Anderson Cancer Center that will support investigation of APR-1051 as a potential treatment for head and neck squamous cell carcinoma (HNSCC).
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Immuno-oncology

IL-13RA2 ADCs disclosed in Exelixis patent

Feb. 13, 2025
Work at Exelixis Inc. has led to the development of antibody-drug conjugates (ADCs) comprising antibodies targeting interleukin-13 receptor subunit α2 (IL-13RA2, IL-13R-α2) covalently linked to a payload. They are described as potentially useful for the treatment of non-small-cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC).
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3D rendering of drug linked to antibody
Immuno-oncology

Alentis Therapeutics’ anti-CLDN1 ADC gains IND clearance

Oct. 3, 2024
Alentis Therapeutics AG has obtained IND clearance from the FDA for ALE.P02, an anti-Claudin-1 (CLDN1) antibody-drug conjugate (ADC) with a tubulin inhibitor payload.
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Chinese flag on flagpole

China’s NMPA accepts NDAs from Innovent, Lepu

Oct. 1, 2024
By Tamra Sami
China’s National Medical Products Administration (NMPA) has accepted NDAs for Innovent Biologics Inc.’s IL-23p19 antibody picankibart to treat moderate to severe plaque psoriasis, and Lepu Biopharma’s antibody-drug conjugate MRG-003, to treat recurrent or metastatic nasopharyngeal cancer.
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