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Home » SARS-CoV-2

Articles Tagged with ''SARS-CoV-2''

Infection

Foundation for Neglected Disease Research discovers new flavonoid compounds for viral infections

Oct. 4, 2024
Foundation for Neglected Disease Research has described flavonoid compounds reported to be useful for the treatment of viral infections.
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Infection

Tohoku University patents new 3CLpro inhibitors

Oct. 1, 2024
Tohoku University has disclosed 3C-like proteinase (3CLpro; Mpro; nsp5) (SARS-CoV-2; COVID-19 virus) inhibitors reported to be useful for the treatment of viral infections and inflammatory disorders.
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Creative rendition of SARS-CoV-2 virus particles.
Infection

Discovery of macrocyclic 3CLpro inhibitors with improved PK properties

Sep. 30, 2024
In work at Shanghai Curegene Pharmaceutical Co. Ltd., synthesis and optimization of a series of SARS-CoV-2 3CL protease (3CLpro, Mpro) inhibitors led to the identification of compounds [I], [II] and [III] as lead candidates suitable for further evaluation, based on their enzymatic IC50s (14, 12 and 8.6 nM, respectively), cellular EC50s (36, 26 and 52 nM, respectively) and human liver microsome (HLM) stability.
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Infection

Discovery and characterization of second-generation oral Mpro inhibitors

Sep. 20, 2024
Details on the work leading to the discovery of the second-generation SARS-CoV-2 main protease (Mpro) inhibitor PF-7817883 (ibuzatrelvir) were disclosed recently by Pfizer Inc. The drug is in phase II clinical development for the treatment of adult individuals with COVID-19 symptoms who are not hospitalized.
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Infection

Insilico Medicine divulges new Mpro inhibitors for SARS-CoV-2

Sep. 19, 2024
Insilico Medicine Inc. has synthesized 3C-like proteinase (3CLpro; Mpro; nsp5) (SARS-CoV-2; COVID-19 virus) inhibitors reported to be useful for the treatment of SARS-CoV-2 infection (COVID-19).
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Infection

Rutgers University divulges new PL-pro inhibitors

Sep. 18, 2024
The State University of New Jersey (Rutgers) has synthesized non-structural protein 3 (nsp3; PL-pro) (SARS-CoV-2; COVID-19 virus) inhibitors reported to be useful for the treatment of viral infections.
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Infection

Ascletis Bioscience synthesizes analogues for COVID-19 treatment

Sep. 12, 2024
Ascletis Bioscience Co. Ltd. has patented nucleoside and nucleotide analogues reported to be useful for the treatment of SARS-CoV-2 infection (COVID-19).
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Other news to note for Sept. 5, 2024

Sep. 5, 2024
Additional early-stage research and drug discovery news in brief, from: Inflarx, Invivyd.
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Infection

Rockefeller University patents new PL-PRO inhibitors for SARS-CoV-2

Aug. 21, 2024
Rockefeller University has disclosed non-structural protein 3 (nsp3; PL-PRO) (SARS-CoV-2; COVID-19 virus) inhibitors reported to be useful for the treatment of SARS-CoV-2 infection (COVID-19).
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Coronavirus, lungs, hand holding stethoscope
Respiratory

Scientists discover gene associated with recovery responses in severe respiratory viral infections

Aug. 20, 2024
By Tamra Sami
Researchers have identified a gene associated with whether patients hospitalized with respiratory viral infections recover rapidly or face life-threatening complications. The gene has the potential to be used as a diagnostic tool or biomarker, which could help triage patients suffering from severe respiratory infections. Having such a biomarker would help clinicians in their early risk assessments to manage their intervention strategies.
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