During the first talk of the Basic Science Seminar sessions at the 2023 EASL International Liver Congress, focusing on the gut-liver axis, Prof. Maria Rescigno from Humanitas University presented data on the interaction between the gut and the liver and the role of microbiota and intestinal permeability in health and disease.
Empress Therapeutics Inc., a Flagship Pioneering firm, has come out of stealth with $50 million in initial funding, a new chief scientific officer and an ambitious plan to file multiple INDs for novel small-molecule compounds over the next two years.
Could a bioactive peptide secreted in the saliva of ticks offer a useful therapy for people who have experienced intracerebral hemorrhage (ICH)? That’s the question Bioxodes SA has set out to answer, and the company is about to move its first-in-class drug candidate, Ir-CPI, which has dual anti-thrombotic and anti-inflammatory effects, into a phase IIa trial in patients with ICH.
Glucocorticoids are very effective immunosuppressive and anti-inflammatory drugs that cause dose-limiting toxicities in brain, liver and bone preventing their use mainly in chronic disorders. Researchers from Immunext Inc. recently reported results from the therapeutic evaluation of the nontoxic glucocorticoid INX-200 with anti-inflammatory efficacy in a once-per-month injection.
PARP14 is an ADP-ribosyltransferase that transfers ADP-ribose from NAD+ onto the appropriate protein target. PARP14 selectively binds to STAT6 and promotes expression of IL-4-regulated genes, thus modulating inflammatory signaling pathways. PARP14 is overexpressed in tissues from patients with dermatomyositis, atopic dermatitis, psoriasis and other inflammatory disorder cells compared to normal tissues.
Moleculight Inc. published a study on the impact of skin pigmentation on the clinical diagnosis of wound infection that could have profound implications for implicit or unconscious racial bias among diagnosticians. The paper in the Journal of Racial and Ethnic Health Disparities pointed to lack of clinical training and educational resources on diverse skin tones and of diagnostic tools to address unique clinical attributes of patients with darker skin tones.
Necroptosis is a well-controlled process of programmed necrosis present in inflammatory disorders mainly regulated by RIPK1, RIPK3 and mixed-lineage kinase domain-like pseudokinase (MLKL).
Reservoir Neuroscience Inc. has disclosed prostaglandin E2 receptor EP2 subtype (PTGER2; EP2) antagonists reported to be useful for the treatment of inflammation.
