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Home » dengue

Articles Tagged with ''dengue''

Takeda, Biological E. partner to widen global access to Qdenga

Feb. 28, 2024
By Tamra Sami
In a move to widen global access to its Qdenga dengue vaccine, Takeda Pharmaceutical Co. Ltd. is partnering with India’s Biological E. Ltd. to manufacture Qdenga (TAK-003).
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Infection

Antiviral activity against dengue infections is enhanced by a CXCR3 antagonist

Feb. 21, 2024
Previous research has shown that upon activation, platelets release CXCL4, influencing replication and propagation of dengue virus (DENV) by increasing the capacity of DENV-2 subtype to bind the CXCR3 receptor on monocytes. At the recent Viruses conference held in Barcelona, researchers from the Translational Health Science & Technology Institute reported the preclinical profile of a CXCR3 antagonist under investigation for the treatment of DENV.
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Structural model of dengue virus.
Infection

2-Thiouridine shows activity against DENV and SARS-CoV-2 ssRNA+ viruses

Oct. 30, 2023
Researchers from Hokkaido University (Japan) and colleagues have identified 2-thiouridine (s2U) as a broad-spectrum antiviral ribonucleoside analogue, by phenotypic screening of a library of 753 nucleoside analogues for antiviral effects. s2U showed antiviral activity against several ssRNA+ viruses, including DENV, SARS-CoV-2 and its variants of concern.
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Mosquito and dengue vaccine
Infection

US DoD awards funding to Codagenix to advance its dengue vaccine

Oct. 25, 2023
Codagenix Inc. announced that the U.S. Department of Defense (DoD), through the U.S. Army Medical Research and Development Command and the U.S. Army Medical Research Acquisition Activity, has awarded the company $5.88 million to advance the development of its Codavax-Denv, a tetravalent live attenuated dengue vaccine program.
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Infection

Grant supports Exevir Bio’s preclinical research on prophylactic and therapeutic solutions for dengue

June 29, 2023
Exevir Bio BV has been awarded a 2-year R&D grant of €1.6 million by Flanders Innovation & Entrepreneurship (VLAIO) for preclinical research towards prophylactic and therapeutic solutions for dengue.
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Infection

Chinese Academy of Sciences institutes divulge new compounds for infection and inflammatory disorders

Jan. 24, 2023
Shanghai Institute of Materia Medica of the Chinese Academy of Sciences and Wuhan Institute of Virology of the Chinese Academy of Sciences have synthesized amide compounds reported to be useful for the treatment of dengue virus infection, skin inflammation, inflammatory joint disease, inflammatory bowel disease and autoimmune disease.
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Bacteria in petri dishes

Potent selective pan-serotype dengue inhibitor developed

Oct. 13, 2021
By John Fox
Blocking the interaction between two dengue virus (DENV) nonstructural proteins, NS3 and NS4B, with a newly developed small-molecule inhibitor resulted in potent antiviral activity in mouse models, according to an international collaborative study led by scientists at the University of Leuven (KU Leuven), CD3 the Centre for Drug Design and Discovery in Leuven, and Janssen Pharmaceutica in Beerse, Belgium.
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Mosquito

Takeda files long-term dengue vaccine data to support EU, other applications

May 25, 2021
By Michael Fitzhugh
New three-year safety and efficacy data on Takeda Pharmaceutical Co. Ltd.'s dengue vaccine candidate, TAK-003, showed it to be 62% more effective than placebo in preventing virologically confirmed infections with the virus and 83.6% more effective than placebo in preventing hospitalizations caused by the mosquito-borne viral disease and due to any of the four dengue virus serotypes in patients ages 4 to 16.
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Mosquito

Takeda files long-term dengue vaccine data to support EU, other applications

May 24, 2021
By Michael Fitzhugh
New three-year safety and efficacy data on Takeda Pharmaceutical Co. Ltd.'s dengue vaccine candidate, TAK-003, showed it to be 62% more effective than placebo in preventing virologically confirmed infections with the virus and 83.6% more effective than placebo in preventing hospitalizations caused by the mosquito-borne viral disease and due to any of the four dengue virus serotypes in patients ages 4 to 16.
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Hands holding petri dish

Antibody protects broadly against flaviviruses, without ADE

Jan. 12, 2021
By John Fox
A study led by Australian researchers at the University of Queensland has shown that a newly developed antibody targets the flavivirus nonstructural protein 1 and was shown to reduce viremia and improve survival in mouse models of dengue, Zika and West Nile infections.
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