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Home » synthetic lethality

Articles Tagged with ''synthetic lethality''

Cells and DNA helix
Newco news

Nodus looks to deleted ‘passenger genes’ in anticancer drive

Sep. 12, 2022
By Nuala Moran
Nodus Oncology Ltd. is set to explore new avenues of DNA damage response by targeting the chromosome next-door neighbors of tumor suppressor genes that are damaged when tumor suppressor genes are inactivated via homozygous deletion. These collaterally deleted ‘passenger genes’ play diverse functions in cell homeostasis and so present a number of molecularly targeted vulnerabilities that can provide a route to destroying cells which carry a tumor suppressor gene.
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Cancer cells under magnifying glass
Newco news

Eisbach Bio surfs synthetic lethal wave

Feb. 4, 2022
By Anette Breindl
“The premise of our whole company is that we target molecular machines, but we don’t target the engine,” Adrian Schomburg told BioWorld. Instead, “we interfere with the throttle and other highly specific controls of these machines.” “We,” in this case, is Eisbach Bio GmbH, a German startup that is developing anticancer programs aimed at exploiting synthetic lethality by targeting helicases. Founded in 2019, the company has three programs, a recently announced collaboration with MD Anderson Cancer Center in oncology, and another program in COVID-19.
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Acute myeloid leukemia illustration

Filling the glass by emptying cancer cells' plates

Oct. 11, 2021
Targeted therapies are a classical example of a glass that can be seen as half full or half empty.
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Synthetic lethality space busy as Viracta launches phase Ib/II trial

Oct. 6, 2021
By Randy Osborne
The start of a phase Ib/II trial with nanatinostat by Viracta Therapeutics Inc. has brought new attention to the burgeoning field of synthetic lethality, where a number of players are piquing the interest of Wall Street.
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Map of China

Impact and Burning Rock team up to develop companion diagnostics for synthetic lethality drugs

Aug. 5, 2021
By David Ho
Burning Rock Biotech Ltd. has formed a global strategic partnership with Impact Therapeutics Inc. to develop companion diagnostics for a pipeline of drugs in the field of synthetic lethality.
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Impact Therapeutics closes $50M series C+ to advance Wee-1 inhibitor and PARP inhibitor

Dec. 8, 2020
By Elise Mak
Chinese biopharma Impact Therapeutics Inc. of Nanjing raised $50 million in a series C+ round on Nov. 30, two years after its $30 million series C round. Impact’s CEO Jun Bao told BioWorld that the majority of the proceeds would be used to take several programs forward. The financing round also paved the way toward an IPO.
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DNA repair

Artios gets $30M up front in DDR-focused deal with Merck; up to $860M per target

Dec. 3, 2020
By Nuala Moran
LONDON – DNA damage repair (DDR) specialist Artios Pharma Ltd. has sealed a $860 million per target deal with Merck KGaA, around a series of small-molecule DNA nuclease inhibitors. The deal, for up to eight targets, will see Artios get $30 million in up-front and near-term milestones to take programs to the point at which Merck will decide on its option to take them in-house. For any products that make it to market, the $860 million in milestones along the way will be followed by double-digit royalties on sales. Subject to certain conditions, Cambridge-based Artios has rights to do joint development with Darmstadt, Germany-based Merck.
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Impact Therapeutics closes $50M series C+ to advance Wee-1 inhibitor and PARP inhibitor

Dec. 2, 2020
By Elise Mak
Chinese biopharma Impact Therapeutics Inc. of Nanjing raised $50 million in a series C+ round on Nov. 30, two years after its $30 million series C round. Impact’s CEO Jun Bao told BioWorld that the majority of the proceeds would be used to take several programs forward. The financing round also paved the way toward an IPO.
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Ideaya, GSK collaboration in synthetic lethality programs in oncology could be worth more than $3B

June 16, 2020
By Lee Landenberger
Glaxosmithkline plc (GSK) will collaborate in three of Ideaya Biosciences Inc.’s synthetic lethality programs, MAT2A (methionine adenosyltransferase 2a), Pol Theta (polymerase theta) and Werner Helicase, in a deal that Ideaya estimated could be worth billions.
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