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Home » tumor microenvironment

Articles Tagged with ''tumor microenvironment''

3D Rendering of tumor microenvironment
Drug design, drug delivery & technologies

AI-based spatial omics unveils molecular talks in tumors

March 26, 2025
By Mar de Miguel
The three-dimensional analysis of cell types and their locations by spatial transcriptomics provides key information of their interactions within tissues or organs. Based on this technology, scientists at the Wellcome Sanger Institute have developed an AI tool called Nichecompass, which shows a comprehensive view of the cancer microenvironments, the different cells, their locations, and how they communicate with each other through different molecules inside the tumor.
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3D Rendering of tumor microenvironment
Drug design, drug delivery & technologies

AI-based spatial omics unveils molecular talks in tumors

March 25, 2025
By Mar de Miguel
The three-dimensional analysis of cell types and their locations by spatial transcriptomics provides key information of their interactions within tissues or organs. Based on this technology, scientists at the Wellcome Sanger Institute have developed an AI tool called Nichecompass, which shows a comprehensive view of the cancer microenvironments, the different cells, their locations, and how they communicate with each other through different molecules inside the tumor. This AI could process data in an hour and compare samples before and after a treatment.
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Art concept for vaccine for cancer
Immuno-oncology

IO-112 modulates tumor macrophages, allows control of tumor microenvironment

Feb. 20, 2025
Io Biotech Aps has presented preclinical data regarding their Arg1-derived peptide cancer vaccine IO-112 as a potential immunotherapeutic that would allow controlling the tumor microenvironment.
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Art concept for targeting a cold tumor
Cancer

Innate immune stimulant helps cold, hurts hot tumor treatment

Feb. 18, 2025
By Coia Dulsat
Immune checkpoint inhibitors (ICIs) have revolutionized the landscape of cancer management. However, acquired resistance and response variability point to rational combination strategies as the goal to achieve significant improvements in the field. Investigators at the National Cancer Center of Japan have found that stimulators of the innate immune response unexpectedly activated suppressive cells of the innate immune system.
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Mestag’s activated fibroblast approach draws Merck in $1.9B deal

Oct. 8, 2024
By Nuala Moran
Mestag Therapeutics Ltd. has sealed a potential $1.9 billion agreement with Merck & Co. Inc., in which it will apply its expertise in activated fibroblasts to identify novel targets for inflammatory diseases. The pharma company has the option to license one or more targets, up to a prespecified number, and will take on all subsequent discovery, development and commercialization work.
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3D Rendering of tumor microenvironment
Immuno-oncology

GI-108, an IL-2-based bifunctional agent that restores cytotoxic activity of immunosuppressed immune cells in TME

Nov. 7, 2023
Researchers from GI Innovation Inc. have developed GI-108, a novel bispecific fusion protein designed to augment antitumor immunity.
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Cancer

B7-H4 as therapeutic target for aggressive adenoid cystic carcinoma tumors

Sep. 6, 2023
Researchers from the MD Anderson Cancer Center presented data from a study that assessed the tumor microenvironment (TME) of adenoid cystic carcinoma (ACC) with the aim of identifying novel therapeutic targets for ACC.
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Cancer cells under magnifying glass
Cancer

Novel potent dual antagonist of the A2A and A2B receptors presented at ACS

Aug. 18, 2023
Targeting the adenosine A2A receptor, a critical mediator of immunosuppression on the tumor microenvironment, has emerged as a strategy to improve cancer immunotherapy, and several A2A receptor antagonists are under clinical evaluation both as monotherapy and in combination with checkpoint inhibitors.
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Tagworks’ click-to-release ADC approach draws $65M in series A round

June 22, 2023
By Nuala Moran
Twelve years on from spinning out of Philips Healthcare, Tagworks Pharmaceuticals BV has raised $65 million in a series A round to take a new generation of antibody-drug conjugates (ADCs) based on click chemistry into the clinic.
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Cancer cells being destroyed by immunotherapy
Immuno-oncology

Anwita Biosciences presents AWT-030, a bifunctional IL-21 fusion protein with enhanced safety, half-life and antitumor activity

April 25, 2023
Researchers from Anwita Biosciences Inc. presented preclinical data for AWT-030, a first-in-class bifunctional IL-21 fusion protein being...
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