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Home » pancreatic ductal adenocarcinoma

Articles Tagged with ''pancreatic ductal adenocarcinoma''

Cancer

Targeted inhibition of both RAS and PIKfyve may offer a promising treatment approach for PDAC

May 2, 2025
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Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a dismal 5-year survival rate of 13%.
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Artistic rendering of the KRAS protein.

AACR 2025: Revolution has early stage KRAS success in NSCLC

April 28, 2025
By Lee Landenberger
Early phase I data for Revolution Medicines Inc.’s RAS(ON) G12D-selective inhibitor zoldonrasib encouraged both the company and the analysts. Initial study data produced a 61% objective response rate in 11 solid tumor patients receiving the 1,200-mg dose once a day. The disease control rate for 16 patients came in at 89%.
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Immuno-oncology

TROP2-targeting antibody-drug conjugate shows promising results in pancreatic cancer

April 28, 2025
Researchers from Heidelberg Pharma AG have presented a new antibody-drug conjugate (ADC) that shows promise for treating pancreatic ductal adenocarcinoma (PDAC). The ADC, called hRS7 ATAC, targets trophoblast cell surface antigen 2 (TROP2), which is overexpressed in most pancreatic tumors and is associated with aggressive disease and poor prognosis.
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Illustration of cancer tumor on pancreas
Cancer

PIKfyve enzyme is target to ‘starve’ pancreatic cancer cells

April 25, 2025
By Mar de Miguel
A metabolic vulnerability of pancreatic ductal adenocarcinoma (PDAC) could be used to address this type of cancer that often resists treatments. Scientists at the University of Michigan have discovered that inhibiting the PIKfyve enzyme prevented tumor development and reduced tumor growth by altering the lipid synthesis these cells rely on. The KRAS-MAPK pathway is involved in this process, leading the researchers to suggest that dual inhibitors of PIKfyve and KRAS-MAPK could be an effective therapeutic strategy.
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3D pancreas illustration
Immuno-oncology

Platform tech reprograms immune responses against KRAS-mutant metastases

April 10, 2025
Pancreatic ductal adenocarcinom a (PDAC), frequently detected at advanced stages, has a 5-year survival rate of 12%. Metastases are common, including hepatic metastasis, which is particularly lethal due to the liver’s immune-tolerant environment and rich blood supply that facilitate tumor growth.
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Human colon cancer cells.
Cancer

Zoldonrasib shows antitumor efficacy in KRAS G12D mutated tumors

March 3, 2025
RAS G12D is one of the most frequent mutations in RAS, and when it occurs, it leaves RAS in a permanently active state, causing the cell to proliferate uncontrollably. Examples of the so-called RAS-addicted cancers are colorectal cancer or pancreatic ductal adenocarcinoma.
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3D illustration of pancreatic cancer
Cancer

Combined strategy can prevent pancreatic cancer drug resistance

Jan. 31, 2025
By Mar de Miguel
Understanding the mechanisms of resistance to cancer treatments is necessary to find effective therapies at different stages of the disease. Scientists at UT Southwestern Medical Center studied the most frequent mutation in pancreatic ductal adenocarcinoma (PDAC), identified an escape route to a therapy in clinical trials, blocked it with another experimental compound and reduced tumors in mice.
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Cancer

TH-301 induces cell cycle arrest, apoptosis and autophagy in human pancreatic cancer cell lines

Jan. 16, 2025
Researchers from University of Athens and National Centre For Scientific Research “Demokritos” have reported preclinical data from a study that aimed to assess the novel cryptochrome-2 (CRY2) stabilizer TH-301 in models of pancreatic ductal adenocarcinoma (PDAC). It was seen that treatment with TH-301 led to significant dose-, time- and cell type-dependent decreases in viability.
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Immuno-oncology

Cancervax selects PDAC as target indication using universal cancer treatment platform

Dec. 12, 2024
Cancervax Inc. has selected pancreatic ductal adenocarcinoma (PDAC) as one of its first targets for preclinical development using its novel universal cancer treatment (UCT) platform.
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Cancer cells under magnifying glass
Cancer

ADT-1004, a promising pan-RAS inhibitor, shows efficacy in PDAC

Nov. 5, 2024
Pancreatic ductal adenocarcinoma (PDAC) has a low 5-year survival rate of <12%. Even though KRAS is mutated in about 88% of PDACs, the KRAS G12C mutation is rare, limiting the use of KRAS G12C inhibitors. Hence, there is a need for pan-RAS inhibitors to cover the broad RAS mutation spectrum in PDAC.
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