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Home » nonalcoholic fatty liver disease

Articles Tagged with ''nonalcoholic fatty liver disease''

A microscopic image of liver tissue affected by metabolic dysfunction-associated steatotic liver disease.
Gastrointestinal

TREM2 receptor linked to NASH progression

Jan. 3, 2023
By Mar de Miguel
Obesity and chronic inflammation in the liver trigger the most severe form of nonalcoholic fatty liver disease (NAFLD), steatohepatitis. Scientists at the University of Texas (UT) have shown how damaged hepatocytes accumulated in the liver after a vicious cycle of cytokine expression induced shedding of a critical liver receptor.
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A microscopic image of liver tissue affected by metabolic dysfunction-associated steatotic liver disease.
Endocrine/Metabolic

Suppression of the somatotrophic axis controls liver damage but produces fibrosis

Dec. 14, 2022
By Mar de Miguel
Liver damage arrests growth mediated by the somatotroph axis, which prevents liver cell death and inflammation, but increases fibrosis in nonalcoholic fatty liver disease (NAFLD). The explanation for this effect could lie in the relationship between the activating transcription factor 3 (ATF-3) and insulin-like growth factor 1 (IGF-1), according to a study from the University of California at Berkeley.
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A microscopic image of liver tissue affected by metabolic dysfunction-associated steatotic liver disease.
Gastrointestinal

TOTUM-448 ameliorates NAFLD signs in obese mice

Nov. 11, 2022
TOTUM-448 is a unique combination of plant extracts designed to reduce hepatic steatosis, a risk factor for nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes.
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Triglyceride fat accumulated inside liver cells
Endocrine/Metabolic

At AASLD 2022, polygenic risk score subtypes in NAFLD

Nov. 8, 2022
By Anette Breindl
Modern molecular techniques have progressed to the point where sequencing can seem almost quaint. At the Basic Science Symposium of the American Association for the Study of Liver Diseases 2022 meeting (AASLD 2022), new techniques were on full display, with sessions devoted to epigenetics, microbiome analysis and spatial transcriptomics. But the first session was still on genetic variants in all their forms – rare variants, common variants and nongermline mutations.
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Liver illustration

At AASLD 2022, polygenic risk score subtypes NAFLD

Nov. 7, 2022
By Anette Breindl
Modern molecular techniques have progressed to the point where sequencing can seem almost quaint. At the Basic Science Symposium of The Liver Meeting 2022, new techniques were on full display, with sessions devoted to epigenetics, microbiome analysis and spatial transcriptomics. But the first session was still on genetic variants in all their forms – rare variants, common variants and non-germline mutations.
Read More
Gastrointestinal

Inipharm presents new HSD17B13 inhibitors

Nov. 3, 2022
Inipharm Inc. has divulged thiazoles/isothiazoles acting as 17-β-hydroxysteroid dehydrogenase 13 (HSD17B13) inhibitors reported to be useful for the treatment of nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, cirrhosis, alcoholic liver disease, drug-induced liver injury and portal hypertension.
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Illustration of stomach, beneficial gut bacteria.

Gut microbiota degrade intestinal nicotine, alleviate smoking-related liver disease

Oct. 25, 2022
By Mar de Miguel
Peking University researchers in collaboration with the NIH have discovered a new biochemical pathway related to a bacterium that eliminates nicotine in the intestine. The findings could lead to new ways to improve nonalcoholic fatty liver disease in smokers.
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Illustration of stomach, beneficial gut bacteria.

Gut microbiota degrade intestinal nicotine, alleviate smoking-related liver disease

Oct. 21, 2022
By Mar de Miguel
Peking University researchers in collaboration with the NIH have discovered a new biochemical pathway related to a bacterium that eliminates nicotine in the intestine. The findings could lead to new ways to improve nonalcoholic fatty liver disease in smokers.
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Gastrointestinal

Gut microbiota degrade intestinal nicotine, alleviate smoking-related liver disease

Oct. 19, 2022
By Mar de Miguel
Peking University researchers in collaboration with the NIH have discovered a new biochemical pathway related to a bacterium that eliminates nicotine in the intestine. The findings could lead to new ways to improve nonalcoholic fatty liver disease (NAFLD) in smokers. In addition to the lung and the brain, nicotine can accumulate in the intestine, where the bacteria Bacteroides xylanisolvens could reduce its concentration and the severity of NAFLD. In their study, published in Nature Oct. 19, 2022, the researchers described the enzymes involved in this process and a new undiscovered pathway.
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Investors scrutinize weight loss data from Altimmune’s fatty liver drug pemvidutide

Sep. 15, 2022
By Richard Staines
Altimmune Inc. has come under scrutiny from investors after weight loss data from a phase Ib trial of its nonalcoholic fatty liver disease drug, pemvidutide, sent its shares on a roller coaster ride.
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