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BioWorld - Friday, July 4, 2025
Home » TKI

Articles Tagged with ''TKI''

Lungs wireframe illustration

US FDA approves J&J’s Rybrevant-Lazcluze combo for lung cancer

Aug. 21, 2024
By Marian (YoonJee) Chu
The U.S. FDA approved Janssen Biotech Inc.’s Rybrevant (amivantamab-vmjw) plus a new oral tyrosine kinase inhibitor called Lazcluze (lazertinib) as a first-line combination treatment to treat select non-small-cell lung cancers.
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Anbogen

Taiwan’s cancer focused Anbogen raises $12.5M in series A round

Feb. 6, 2024
By Marian (YoonJee) Chu
Taipei-based precision oncology firm Anbogen Therapeutics Inc. drew $12.5 million in a series A funding round to propel two major clinical assets in its cancer pipeline.
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Anbogen

Taiwan’s cancer focused Anbogen raises $12.5M in series A round

Feb. 2, 2024
By Marian (YoonJee) Chu
Taipei-based precision oncology firm Anbogen Therapeutics Inc. drew $12.5 million in a series A funding round to propel two major clinical assets in its cancer pipeline.
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With MFDS expanded approval, Yuhan's Leclaza moving to first-line NSCLC treatment

July 11, 2023
By Marian (YoonJee) Chu
South Korean pharmaceutical giant Yuhan Corp. gained Korea’s MFDS approval to expand indications for its potent oral third-generation tyrosine kinase inhibitor Leclaza (lazertinib) as a first-line treatment for EGFR T790M mutation-positive non-small-cell lung cancer (NSCLC).
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With MFDS expanded approval, Yuhan's Leclaza moving to first-line NSCLC treatment

July 5, 2023
By Marian (YoonJee) Chu
South Korean pharmaceutical giant Yuhan Corp. gained Korea’s MFDS approval to expand indications for its potent oral third-generation tyrosine kinase inhibitor Leclaza (lazertinib) as a first-line treatment for EGFR T790M mutation-positive non-small-cell lung cancer (NSCLC).
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Grey dollar sign on grey background

Idrx achieves ‘no-escape’ velocity with $122M for combo bid to tackle GIST mutations

Aug. 2, 2022
By Randy Osborne
Idrx Inc. launched with a $122 million oversubscribed series A round to boost precision drug combinations in cancer, with a first focus on non-PDGFR-driven gastrointestinal stromal tumors (GIST). The Plymouth, Mass.-based firm aims to develop a pairing, potentially with add-ons, powerful enough to handle existing mutations and those that turn up during treatment. Combo therapy attacks “not just the driver mutations, but also the key secondary mutations,” co-founder and CEO Ben Auspitz told BioWorld, and thereby “block every escape route the cancer has.”
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Allist's furmonertinib meets primary endpoint in phase III trial to treat lung cancer

April 12, 2022
By Doris Yu
Shanghai Allist Pharmaceuticals Co. Ltd.’s third-generation EGFR tyrosine kinase inhibitor, furmonertinib, met its primary endpoint in a phase III trial, demonstrating longer progression-free survival vs. first-generation EGFR TKI Iressa (gefitinib, Astrazeneca plc) as first-line therapy for locally advanced or metastatic EGFR mutation-positive non-small-cell lung cancer.
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Allist's furmonertinib meets primary endpoint in phase III trial to treat lung cancer

April 6, 2022
By Doris Yu
Shanghai Allist Pharmaceuticals Co. Ltd.’s third-generation EGFR tyrosine kinase inhibitor, furmonertinib, met its primary endpoint in a phase III trial, demonstrating longer progression-free survival vs. first-generation EGFR TKI Iressa (gefitinib, Astrazeneca plc) as first-line therapy for locally advanced or metastatic EGFR mutation-positive non-small-cell lung cancer.
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Lung cancer illustration

Overcoming EGFR-targeted TKI lung cancer resistance

Oct. 14, 2021
By John Fox
A novel pharmacologically targetable metabolic mechanism driving resistance to epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitors (TKIs) has been identified in preclinical models of lung cancer in a Chinese study led by scientists at Shanghai Jiao Tong University School of Medicine.
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Fingerprints in shape of lungs with magnifying glass and DNA

As targeted options expand, making the best match, and the most matches

Sep. 20, 2021
By Anette Breindl
Researchers have retrospectively divided more than 16,000 non-small-cell lung cancer (NSCLC) patients with EGFR mutations into four structure-based subgroups, and looked at how the members of each subgroup fared depending on which EGFR inhibitor they were given.
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