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Home » WRN inhibitors

Articles Tagged with ''WRN inhibitors''

Cancer

DAT-5000A has potency against tumors with microsatellite instability

May 16, 2025
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Werner syndrome ATP-dependent helicase (WRN) is an enzyme involved in DNA replication and repair and has been identified as a synthetic lethality target in tumors with high microsatellite instability (MSI-H).
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Cancer

New inhibitors of the WRN helicase show preclinical promise for MSI-high colorectal cancers

May 16, 2025
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Microsatellite instability (MSI), which results from defects in the DNA mismatch repair system, is an important biomarker in colorectal cancer. While the MSI-high (MSI-H) status predicts response to pembrolizumab, a commonly used immune checkpoint inhibitor in metastatic colorectal cancer, a subset of MSI-H patients still does not respond to this treatment.
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Cancer

Starg (Wuhan) Pharmaceutical discovers new WRN inhibitors

May 5, 2025
Starg (Wuhan) Pharmaceutical Technology Co. Ltd. has described Werner syndrome ATP-dependent helicase (WRN; RECQ3; RECQL2) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Moma Therapeutics patents new WRN inhibitors

April 4, 2025
Moma Therapeutics Inc. has disclosed tricyclic derivatives acting as Werner syndrome ATP-dependent helicase (WRN; RECQ3; RECQL2) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Eikon Therapeutics describes new WRN inhibitors

March 21, 2025
Eikon Therapeutics Inc. has identified Werner syndrome ATP-dependent helicase (WRN; RECQ3; RECQL2) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Kinoteck Therapeutics patents new WRN inhibitors

March 19, 2025
Kinoteck Therapeutics Co. Ltd. has disclosed Werner syndrome ATP-dependent helicase (WRN; RECQ3; RECQL2) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Haisco Pharmaceutical discovers new WRN inhibitors

Feb. 19, 2025
Haisco Pharmaceutical Group Co. Ltd. has described Werner syndrome ATP-dependent helicase (WRN; RECQ3; RECQL2) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Nimbus Wadjet patents new WRN inhibitors

Jan. 7, 2025
Nimbus Wadjet Inc. has disclosed compounds reported to be useful for the treatment of cancer.
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Cancer

Inventisbio scientists discover new WRN inhibitors

Dec. 9, 2024
Researchers at Inventisbio Co. Ltd. and Inventisbio LLC have described Werner syndrome ATP-dependent helicase (WRN; RECQ3; RECQL2) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Beijing Danatlas Pharmaceutical Technology patents new WRN inhibitors

Nov. 28, 2024
Beijing Danatlas Pharmaceutical Technology Co. Ltd. has disclosed Werner syndrome ATP-dependent helicase (WRN; RECQ3; RECQL2) inhibitors reported to be useful for the treatment of cancer.
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