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Home » fusion proteins

Articles Tagged with ''fusion proteins''

Hands holding gears

Ono inks deals with Shattuck, Numab in autoimmune disease, oncology

Feb. 15, 2024
By Tamra Sami
Ono Pharmaceutical Co. Ltd. inked deals with Shattuck Labs Inc. and Numab Therapeutics AG aimed at bolstering its pipeline in oncology and autoimmune and inflammatory diseases. Ono struck a drug discovery collaboration and option agreement with Shattuck Labs to generate bifunctional fusion proteins for pathways involved in autoimmune and inflammatory diseases. It also signed a global research, development and commercialization deal with Numab for its NM-49, a multispecific antibody designed to activate tumor-associated macrophage phagocytosis for treating cancers.
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Musculoskeletal

Aurinia submits IND for AUR-200 for autoimmune diseases

Dec. 22, 2023
Aurinia Pharmaceuticals Inc. has submitted an IND application to the FDA for AUR-200, a potential next-generation therapy for B-cell-mediated autoimmune diseases.
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3D Rendering of tumor microenvironment
Immuno-oncology

GI-108, an IL-2-based bifunctional agent that restores cytotoxic activity of immunosuppressed immune cells in TME

Nov. 7, 2023
Researchers from GI Innovation Inc. have developed GI-108, a novel bispecific fusion protein designed to augment antitumor immunity.
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3D representation of tumor
Immuno-oncology

VEGF- and PlGF-targeting fusion protein inhibits tumor progression by activating antitumor immunity

Oct. 13, 2023
Researchers from Panolos Bioscience Inc. and affiliated organizations have published preclinical data for PB-101, a novel glycosylated decoy protein targeting both vascular endothelial growth factor (VEGF) and placental growth factor (PlGF).
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Colorful illustration of the heart
Endocrine/Metabolic

AT-02, a humanized IgG1-peptide fusion reagent that potently binds cardiac amyloid

Aug. 30, 2023
At the recent ESC Congress, researchers from University of Tennessee and Attralus Inc. presented preclinical data on the novel pan-amyloid-binding peptide fusion immunoglobulin AT-02, which is being developed for the treatment of amyloidosis.
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Fundus image of eye with age-related macular degeneration.
Ocular

EXG-102-031 demonstrates preclinical safety and efficacy in models of neovascular AMD

May 22, 2023
At the recent ASGCT meeting, researchers from Exegenesis Bio Inc. presented preclinical data for EXG-102-031, a novel recombinant adeno-associated virus (rAAV)-gene therapy being developed for the treatment of neovascular age-related macular degeneration (AMD), also called wet AMD (wAMD).
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Natural killer cell attacking cancer cell
Cancer

ZW-270, a masked IL-12 fusion protein, shows superior antitumor efficacy in preclinical studies

May 11, 2023
Interleukin-12 (IL-12) is a pleiotropic cytokine designated as a cytotoxic lymphocyte maturation factor and NK cell stimulator that interconnects innate and adaptive immunity. Studies in animal models have shown antitumor effects, but its translation into the clinic has been often linked to unacceptable toxicity.
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Cancer cells being destroyed by immunotherapy
Immuno-oncology

Anwita Biosciences presents AWT-030, a bifunctional IL-21 fusion protein with enhanced safety, half-life and antitumor activity

April 25, 2023
Researchers from Anwita Biosciences Inc. presented preclinical data for AWT-030, a first-in-class bifunctional IL-21 fusion protein being...
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Endocrine/Metabolic

Fusion protein has metabolic benefits in mice, primates

Feb. 8, 2023
By Mar de Miguel
Treatment with the fusion protein QL-1005 reduced caloric intake and body weight in mice and primates. In obese animals, it also improved insulin, fasting glucose and triglyceride levels. The design belongs to the Chinese biopharmaceutical company Beijing QL Biopharmaceutical, which will begin clinical trials in a year.
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3D renderings of RSV
Respiratory

Targeting prefusion state is better bet for RSV vaccines

Jan. 5, 2023
By Mar de Miguel
After comparing the response to the two types of vaccines for the respiratory syncytial virus (RSV) based on its fusion protein (F), prefusion (pre-F) versus postfusion (post-F) vaccines, scientists at the National Institutes of Health (NIH) and Astrazeneca plc have demonstrated that targeting the pre-F protein led to better protection. No more bets on RSV immunization based on the post-F protein of the virus. Laboratories can now bet all on red for the pre-F technology.
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