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Home » Hanmi Pharmaceutical Co. Ltd.

Articles Tagged with ''Hanmi Pharmaceutical Co. Ltd.''

Cancer

Hanmi Pharmaceutical discloses new YAP1/TEAD interaction inhibitors

July 21, 2025
Hanmi Pharmaceutical Co Ltd. has synthesized new heterobicyclic compounds acting as transcriptional coactivator YAP1/transcriptional enhancer factor (TEAD) interaction inhibitors and reported to be useful for the treatment of cancer.
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Cancer

Hanmi Pharmaceutical discovers new SOS1 inhibitors

April 23, 2025
Hanmi Pharmaceutical Co. Ltd. has described son of sevenless homolog 1 (SOS1) inhibitors reported to be useful for the treatment of cancer.
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Handshake with digital globe overlay

Merck strikes a $2B GLP-1 deal with Hansoh

Dec. 24, 2024
By Lee Landenberger
Merck & Co. Inc. has turned to Asia for a second time to get into the GLP-1 market, this time to Shanghai-based Hansoh Pharmaceutical Group Co. Ltd. for its investigational preclinical oral small-molecule GLP-1 receptor agonist. Hansoh is getting $112 million up front and could bring in another $1.9 billion in milestone payments. Merck said the addition to its GLP-1 arsenal is “to provide additional cardiometabolic benefits beyond weight reduction.”
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Handshake with digital globe overlay

Merck strikes a $2B GLP-1 deal with Hansoh

Dec. 18, 2024
By Lee Landenberger
Merck & Co. Inc. has turned to Asia for a second time to get into the GLP-1 market, this time to Shanghai-based Hansoh Pharmaceutical Group Co. Ltd. for its investigational preclinical oral small-molecule GLP-1 receptor agonist. Hansoh is getting $112 million up front and could bring in another $1.9 billion in milestone payments. Merck said the addition to its GLP-1 arsenal is “to provide additional cardiometabolic benefits beyond weight reduction.”
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Endocrine/metabolic

HM-17321, a CRFR2-selective UCN2 analogue with efficacy in models of obesity

Nov. 22, 2024
Urocortin-2 (UCN2) is a selective corticotropin-releasing factor CRF2 receptor (CRFR2) agonist, which has been previously shown to reduce fat mass while promoting muscle hypertrophy. Hanmi Pharmaceutical Co. Ltd. presented the discovery and preclinical characterization of a novel CRFR2-selective UCN2 analogue, HM-17321, being developed for the treatment of obesity.
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Cancer

SOS1 inhibitor HM-99462 demonstrates synergy with RTK-KRAS-MAPK signaling inhibitors

Nov. 8, 2024
SOS1 is a guanine nucleotide exchange factor (GEF) that activates KRAS, and recent preclinical studies have demonstrated that combining KRAS and EGFR inhibitors with SOS1 inhibitors can overcome resistance and achieve durable responses.
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Lab glassware and scientist
Cancer

HM-100760 targets MTAP-deleted cancers via synthetic lethality

Oct. 31, 2024
Methionine adenosyltransferase 2A (MAT2A), the rate-limiting enzyme in the methionine cycle, catalyzes the formation of S-adenosylmethionine (SAM) from methionine and adenosine triphosphate (ATP).
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Novo Nordisk to launch Wegovy in South Korea mid-October

Oct. 7, 2024
By Marian (YoonJee) Chu
Danish pharma giant Novo Nordisk A/S is set to launch its blockbuster glucagon-like peptide-1 therapy, Wegovy (semaglutide), in South Korea’s growing obesity therapeutics market next week, a company official confirmed to BioWorld.
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Alpha-galactosidase enzyme
Endocrine/metabolic

GC Biopharma and Hanmi’s once-monthly subcutaneous treatment for Fabry disease gains US IND clearance

Sep. 3, 2024
The FDA has cleared an IND for a phase I/II trial of LA-GLA (GC-1134A, HM-15421), an innovative enzyme replacement therapy for Fabry disease being co-developed by GC Biopharma Corp. and Hanmi Pharmaceutical Co. Ltd.
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Test tube, dropper, DNA illustration
Endocrine/metabolic

US orphan drug status granted to Hanmi and GC Biopharma candidate for Fabry disease

May 28, 2024
The U.S. FDA has granted orphan drug status to HM-15421 (GC-1134A, LA-GLA) for the treatment of Fabry disease.
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