Organoids grown from cholangiocytes – the epithelial cells of the bile duct – are poised to be used in ex vivo cell therapy to increase the number of donated livers that are suitable for transplant, and also for direct bile duct repairs.

BioWorld looks at translational medicine, including: Metabolic changes are antibiotic resistance mechanism; Tumor neoantigens can inhibit immune response; Chromosome organization machinery linked to DNA repair.

The molecular mechanisms underlying control of antibiotic production by hormones in soil bacteria have been elicited for the first time in a study by scientists at University of Warwick in Coventry, U.K., and at Monash University in Melbourne, Australia.

Researchers at Thomas Jefferson University have implanted brain electrodes in a patient who suffered a subcortical ischemic stroke more than a year ago to help them overcome abnormal muscle tone and control a robotic arm brace. Artificial intelligence (AI) algorithms interpret neuronal signals recorded by the electrodes into movement of the brace.

A study by researchers at Nanjing University has demonstrated that in mice, depression-like phenotypes induced by paternal stress can be inherited by the offspring through a causal role of microRNAs in the father's sperm.

Researchers at Hannover Medical School have developed an organoid that mimicked the early codevelopment of the heart with liver, lung and blood vessels.

A study led by scientists at the Korean Research Institute of BioScience and Biotechnology in Daejeon is the first to demonstrate that Dilp8/INSL3-Lgr3/8-NUCB, neuropeptide y signaling may be a potential therapeutic target in cancer anorexia and cachexia, which is associated with increased cancer mortality.