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Home » Topics » Conferences, BioWorld Science

Conferences, BioWorld Science
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Illustration of triple-negative breast cancer cells
Diagnostics

New radiotracer shows encouraging results in TNBC

July 7, 2025
No Comments
One of the functions of tumor-associated macrophages (TAMS) is to protect the tumor against the immune system, inhibiting T-cell engagement and reducing the efficacy of checkpoint inhibitors. Polyamidoamine hydroxyl dendrimers (HDs) target TAM without the need of a targeting ligand and are retained by TAMs for up to 1 month allowing radiation to deposit in the tumor.
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3D rendering conceptualizing theranostics
Cancer

Theranostic agent for CA9-expressing tumors presented

July 7, 2025
No Comments
Carbonic anhydrase IX (CAIX, CA9) is a membrane-associated isoform of the α-carbonic anhydrase enzyme family, involved in pH regulation and the acidification of the tumor microenvironment (TME) in solid tumors. It is widely recognized as a marker of tumor hypoxia and serves as a prognostic indicator in multiple human cancers.
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Illustration of monoclonal antibody hovering between doctor's hands
Immune

Oxion’s anti-OX40L antibody shows potential for disease-modifying effects

July 7, 2025
No Comments
The OX40/OX40L costimulatory pathway is crucial for effective T-cell activation and is inducibly expressed in response to immunological stimulation. Targeting OX40L has demonstrated safety and efficacy in preclinical studies using nonhuman primate models of kidney and heart transplantation.
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Peptide illustration
Endocrine/metabolic

Insparin, a promising antidiabetic peptide

July 4, 2025
No Comments
Insparin is a protein isolated from human adenovirus Ad36 that induces cellular glucose uptake without impacting safety. A preclinical study of insparin looked at its potential antidiabetic effects compared to those of pioglitazone.
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3D heart in chest
Cardiovascular

At CRVBC 2025: Aging is circulating in your blood

July 4, 2025
By Mar de Miguel
No Comments
All kinds of substances circulate through the bloodstream. Some are beneficial, like oxygen or nutrients, and others less so, like waste products, toxins, pathogens and certain trafficking cells. Among these harmful substances are deleterious factors associated with aging, which can prematurely damage different tissues. The big question is what are those factors that mediate such effects, and what can be done to prevent them. The 11th Cardiac Regeneration and Vascular Biology Conference, held on the Island of San Servolo, Venice, from June 30 to July 2, 2025, included presentations, oral sessions and posters addressing the impact of aging on the cardiovascular system.
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Pills, bottle, scale and-measuring tape
Endocrine/metabolic

Eccogene’s ECC-4703 leads to greater weight loss in preclinical studies

July 3, 2025
No Comments
Glucagon-like peptide 1 receptor (GLP-1R) agonism is a validated approach for treating obesity. ECC-4703 is a small molecule and liver-targeting compound developed by Eccogene Co. Ltd. It is an agonist of thyroid hormone receptor β (THR-β) and its metabolic impact on preclinical models of obesity in combination with semaglutide was investigated.
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Microscopic image of clear cell carcinoma, the most common type of renal cell carcinoma.
Cancer

[68Ga]NXK-44 radiotracer arises as a promising agent for RCC

July 3, 2025
No Comments
Chinese researchers from Huazhong University of Science and Technology have developed a novel carbonic anhydrase IX (CAIX)-targeting radiotracer, [68Ga]NXK-44, for the imaging of hypoxic tumors and renal cell carcinoma (RCC).
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3D illustration of transparent human torso with close up of spinal cord
Musculoskeletal

GRWD-0715 blocks pathogenic T-cell activation in axial spondyloarthritis

July 3, 2025
No Comments
Researchers from Grey Wolf Therapeutics Ltd. presented the preclinical characterization of GRWD-0715, a selective ERAP1 inhibitor developed as a disease-modifying therapeutic approach aimed at preventing CD8+ T-cell activation and the subsequent tissue inflammation and damage associated with autoimmune conditions.
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Woman measuring her body fat with caliper
Endocrine/metabolic

ASC-47 shows superior weight loss effect compared to semaglutide

July 2, 2025
No Comments
ASC-47 is a thyroid hormone receptor β agonist, muscle-preserving weight loss compound for treating obesity developed by Ascletis Pharma Inc. ASC-47 demonstrated a half-life of 26 and 40 days in healthy subjects and in patients with obesity, respectively.
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Cell research illustration
Inflammatory

Immune checkpoint enhancer ALTB-268 decreases inflammation

July 2, 2025
No Comments
Agonists of immune checkpoint modulators for treating autoimmune and inflammatory disorders have shown high potential in immunotherapy. P-selectin glycoprotein ligand 1 (PSGL-1) is known to exert immune checkpoint regulator functions in T cells aside from its classic role as an adhesion molecule involved in leukocyte trafficking.
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