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Home » Topics » Cancer, BioWorld Science

Cancer, BioWorld Science
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Cancer

Chengdu Zeling Biomedical Technology discovers new PARP-1 inhibitors

May 20, 2025
Chengdu Zeling Biomedical Technology Co. Ltd. has described poly(ADP-ribose) polymerase 1 (PARP-1; ARTD1) inhibitors reported to be useful for the treatment cancer.
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Cancer

New FABP inhibitors disclosed in patent

May 20, 2025
Scientists at Jubilant Biosys Ltd. and the University of Texas System have divulged fatty acid binding protein (FABP) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Roche describes new GTPase KRAS mutant inhibitors

May 20, 2025
Scientists at F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have identified macrocyclic compounds acting as GTPase KRAS (G12D mutant) and/or (G13D mutant) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Bristol Myers Squibb patents new BCL-6 degradation inducers

May 20, 2025
Bristol Myers Squibb Co. has disclosed proteolysis targeting chimera (PROTAC) compounds comprising a cereblon (CRBN) E3 ubiquitin ligase-binding moiety covalently bonded to a B-cell lymphoma 6 protein (BCL-6)-targeting moiety through a linker. They are reported to be useful for the treatment of cancer and autoimmune diseases.
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3D Rendering of tumor microenvironment
Immuno-oncology

New oncolytic virus expressing FLT3L enhances antitumor immunity by activating dendritic cells

May 20, 2025
No Comments
Oncolytic viruses trigger immunogenic cell death in tumors, releasing signals that activate innate immune cells and promote tumor-specific T-cell responses. While some oncolytic viruses, including FDA-approved T-VEC, have shown safety and some clinical benefit, their limited effectiveness as standalone treatments underscores the need for combination therapies.
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Photomicrograph of diffuse large B-cell lymphoma
Cancer

MALT1 inhibitor SY-12696 proves efficient for treating BTKi-resistant DLBCL

May 20, 2025
No Comments
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is an important factor from a complex downstream of Bruton tyrosine kinase (BTK) in the B-cell receptor (BCR) signaling pathway.
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CAR T cell attacking cancer cells
Immuno-oncology

PRGN-3008 exerts potent antitumoral activity and surpasses conventional CAR T

May 20, 2025
No Comments
CAR T-cell therapy for B-cell malignancies has still to be improved regarding durability, manufacturing complexity or toxicity, among others. Precigen Inc. has presented data regarding the preclinical development and efficacy of PRGN-3008, a PD-1-expression inhibitor cell therapy targeting CD19 that was built in a next-generation ultra CAR T platform.
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Cancer

Rationalizing the design of styrylquinolinium derivatives to bind c-Myc G-quadruplexes in breast cancer

May 20, 2025
No Comments
Breast cancer is the most frequent malignancy among women worldwide, and all subtypes of breast cancer involve upregulation of the c-Myc gene, making it a compelling therapeutic target. G-rich regions of the c-Myc promoter can form G-quadruplex structures, which can be targeted using small molecules containing a styrylquinolinium core, which then downregulate oncogenic c-Myc. The challenge, however, is specificity.
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Woman receiving radiotherapy treatments for cancer
Cancer

Amphiregulin drives metastasis through a paradoxical ‘badscopal’ effect of radiotherapy

May 20, 2025
By Coia Dulsat
No Comments
Researchers at the University of Chicago have shed light on the role of tumor-promoting factors induced by radiotherapy and their potential impact on future therapeutic strategies. The article, published in Nature on May 14, 2025, points to radiation-induced amphiregulin as a key driver of tumor metastasis.
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Cancer cells being destroyed by immunotherapy
Cancer

Avidicure boosting immune activation with $50M seed round

May 19, 2025
By Nuala Moran
No Comments
Newco Avidicure NV arrived on the scene with a hefty $50 million in seed funding to advance novel antibody formats the company says will surpass the best qualities of first-generation antibodies, checkpoint inhibitors, T-cell engagers and antibody-drug conjugates.
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