Major histocompatibility complex (MHC) class II molecules aberrantly induced by viral infection or inflammation, have been shown for the first time to form self-antigen/MHC class II complexes that initiate autoantibody production, according to a Japanese study published in the March 4, 2022, edition of Science Advances.

An international collaboration led by scientists at The University of South Australia, SA Pathology in Adelaide, and the de Duve Institute, University of Louvain, Belgium, has discovered biallelic MDFIC pathogenic variants underlying the severe lymphatic disorder, central conducting lymphatic anomaly (CCLA), in seven people from six separate families.