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Home » Topics » Antibody, BioWorld Science

Antibody, BioWorld Science
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Antibodies attacking cancer cell
Immuno-oncology

New anti-CCR8 immuno-oncology antibodies with unique binding/pharmacology

May 15, 2025
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CCR8 is highly expressed on immunosuppressive regulatory T cells (Tregs) in various solid tumors, making it a potential target to enhance antitumor immunity and the efficacy of cancer therapies, including checkpoint inhibitors. However, the impact of CCR8 expression on the Treg phenotype and its role in cancer progression remain unclear.
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Acute myeloid leukemia illustration
Immuno-oncology

The humanized antibody hu128.1 targeting TfR1 shows preclinical potential for erythroleukemia

May 12, 2025
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A recent study explored the therapeutic potential of hu128.1, a humanized antibody targeting transferrin receptor 1 (TfR1), in treating erythroleukemia using xenograft mouse models. The results demonstrate that hu128.1 exerts strong antitumor activity against human erythroleukemic (ERY-1) cells, highlighting its promise as a candidate for managing this aggressive cancer.
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Immuno-oncology

Beigene’s BGB-A3055 inhibits tumor growth in cancer rodent models

May 7, 2025
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Beigene Co. Ltd. has presented data on their anti-CCR8 antibody BGB-A3055 as a cancer immunotherapeutic approach.
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Immuno-oncology

Xenothera details preclinical characterization of XON-9

May 6, 2025
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Hepatocellular carcinoma (HCC) is the second leading cause of cancer-associated deaths worldwide.
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Antibodies
Immuno-oncology

A single antibody to attack two epitopes for cholangiocarcinoma driven by FGFR2 fusions

April 30, 2025
Abnormal fusion of the FGFR2 gene, encoding the fibroblast growth factor receptor 2, occurs in several types of cancer, including in up to 15% of cases of intrahepatic cholangiocarcinoma.
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Multiple myeloma illustration
Immuno-oncology

QLS-4131 designed to address unmet medical needs in multiple myeloma

April 30, 2025
Multiple myeloma (MM) is a complex disease with poor prognosis and its clinical management still remains a challenge in the field. Since both BCMA and GPRC5D are overexpressed in MM cells, a therapeutic approach targeting both would be of interest. Qilu Pharmaceutical Co. Ltd. is hence developing a dual BCMA- and GPRC5D-targeting antibody – QLS-4131 – for the treatment of MM.
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Biotech deal illustration
Neurology/psychiatric

Seed financing at Genrab to advance neuroprotective antibody therapies toward clinic

April 25, 2025
Genrab Inc. has completed a private placement with aggregate gross proceeds of $5.6 million dollars.
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Antibodies illustration
Inflammatory

Granite Bio emerges from stealth with focus on antibodies for inflammatory, autoimmune and fibrotic conditions

April 25, 2025
Granite Bio AG has emerged from stealth with $100 million in series A and B funding and a focus on developing first-in-class antibodies that target the root causes of a variety of inflammatory, autoimmune and fibrotic conditions.
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Antibodies attacking cancer cell
Immuno-oncology

Avidicure launches with focus on multifunctional antibodies to treat cancer

April 25, 2025
Avidicure BV has launched with a $50 million seed financing round and a focus on developing dual agonistic, multifunctional and avidity engineered antibodies, or AVC-Boosters, to deliver targeted and potent cancer monotherapy.
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Immuno-oncology

Anticancer antibodies that effectively neutralize the G protein-coupled receptor CXCR2

April 22, 2025
G protein-coupled receptors (GPCRs) are involved in many diseases, yet raising therapeutic antibodies against them is notoriously difficult because the transmembrane receptors contain only short extracellular regions that can function as antigens. As a result, only two therapeutic antibodies against GPCRs have ever been licensed for the clinic.
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