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Home » Topics » Antibody-drug conjugate, BioWorld Science

Antibody-drug conjugate, BioWorld Science
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Cancer cells being destroyed by immunotherapy
Cancer

Avidicure boosting immune activation with $50M seed round

May 19, 2025
By Nuala Moran
No Comments
Newco Avidicure NV arrived on the scene with a hefty $50 million in seed funding to advance novel antibody formats the company says will surpass the best qualities of first-generation antibodies, checkpoint inhibitors, T-cell engagers and antibody-drug conjugates.
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3D rendering of an antibody drug conjugate
Immuno-oncology

Data support benefit of MUC1*-targeted ADCs in trastuzumab-resistant patients

May 19, 2025
No Comments
Minerva Biotechnologies Corp. recently released details on their work to develop a treatment for HER2-positive patients who have acquired resistance to Herceptin (trastuzumab) or Enhertu (trastuzumab-deruxtecan).
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Cancer

ADC Therapeutics patents new anti-NaPi2b conjugates

May 16, 2025
ADC Therapeutics SA has described antibody-drug conjugates comprising antibody targeting sodium-dependent phosphate transport protein 2B (SLC34A2; NaPi-2b) covalently linked to exatecan through a linker reported to be useful for the treatment of ovarian cancer and non-small-cell lung cancer (NSCLC).
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Immuno-oncology

BB-1705 optimizes profile of EGFR-targeting therapies

May 13, 2025
No Comments
Epidermal growth factor receptor (EGFR), when overactive or overexpressed, may lead to tumor growth and spread, and is thus a robust target for therapy.
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Immuno-oncology

SYS-6041 shows promise for treating FOLR1-expressing cancers

May 9, 2025
No Comments
Folate receptor α (FOLR1) is highly expressed in the surface of tumoral cells in several cancer types, while it shows limited expression in normal tissues. CSPC Pharmaceutical Group Ltd. has developed a next-generation antibody-drug conjugate (ADC) targeting FOLR1 – SYS-6041 – for the treatment of mid-to-low FOLR1-expressing tumors.
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Immuno-oncology

Anti-CLDN6 QLS-5132 found to have broader therapeutic window

May 9, 2025
No Comments
Claudin-6 (CLDN6) is a protein found in the tight junctions of epithelial cells to modulate their permeability and barrier function, among other actions.
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Immuno-oncology

ADCE-T02 ADC against tissue factor shows strong antitumor activity

May 8, 2025
No Comments
The expression of tissue factor (TF) is limited in normal tissues to the perivascular compartment where it acts as the receptor for the serin protease factor VIIa. This signaling axis triggers the initiation of extrinsic coagulation protease cascade.
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3D illustration of human digestive system
Immuno-oncology

LM-350 shows strong antitumor activity in CDH17-positive models

May 7, 2025
No Comments
Cadherin 17 (CDH17) is a membrane-bound cell adhesion molecule involved in tumor cell proliferation and is selectively overexpressed in several gastrointestinal malignancies, including colorectal cancer, gastric cancer and pancreatic cancer.
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Antibody-drug conjugate
Immuno-oncology

Formosa and Almac Discovery sign license agreement for EGFRxROR1 bispecific ADC

May 7, 2025
No Comments
Formosa Pharmaceuticals Inc. and Almac Discovery Ltd. have announced a global licensing agreement for development and commercialization of ALM-401, a first-in-class engineered bispecific antibody-drug conjugate (ADC) for the treatment of solid tumors characterized by the dual expression of EGFR and ROR1.
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Immuno-oncology

Tyligand develops new dual-action tumor immune agonists for cancer treatment

May 5, 2025
No Comments
Tyligand Bioscience Ltd. has reported data on TSN-222, their new cyclic dinucleotide designed as a dual-action tumor immune agonist (DATIA) compound.
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