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BioWorld - Wednesday, August 13, 2025
Home » Topics » Drugs » Antibody-drug conjugate

Antibody-drug conjugate
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Floating antibody drug conjugates

Minghui closes $131M pre-IPO round for PD-1/VEGF antibody, ADCs

Aug. 12, 2025
By Marian (YoonJee) Chu
No Comments
Minghui Pharmaceutical Ltd. announced it is raising $131 million in a pre-IPO financing round Aug. 7. The funds will be used to advance its cancer and inflammatory disease pipeline, which include a PD-1/VEGF bispecific antibody, antibody-drug conjugates (ADCs) and a topical Janus kinase inhibitor.
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Floating antibody drug conjugates

Minghui closes $131M pre-IPO round for PD-1/VEGF antibody, ADCs

Aug. 8, 2025
By Marian (YoonJee) Chu
No Comments
Minghui Pharmaceutical Ltd. announced it is raising $131 million in a pre-IPO financing round Aug. 7. The funds will be used to advance its cancer and inflammatory disease pipeline, which include a PD-1/VEGF bispecific antibody, antibody-drug conjugates (ADCs) and a topical Janus kinase inhibitor.
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Cancer

Shanghai Ruotuo Biotechnology presents new HER2-targeting ADCs

Aug. 6, 2025
Shanghai Ruotuo Biotechnology Co. Ltd. has identified antibody-drug conjugates consisting of antibodies targeting HER2 (erbB2) covalently linked to camptothecin derivatives through a linker reported to be useful for the treatment of cancer.
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3D rendering of antibody drug conjugated with cytotoxic payload
Cancer

7MW-4911 is new ADC for overcoming resistance in GI tumors

Aug. 6, 2025
No Comments
Cadherin 17 (CDH17), a member of the cadherin family protein involved in intestinal development and cell adhesion, is recognized as a potential therapeutic target in gastrointestinal (GI) cancers. Its tumor-specific overexpression and limited presence in normal tissues offer a favorable profile for the development of selective, targeted treatments.
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T cells attacking cancer cells

Lepu out-licenses T-cell engagers to newco Excalipoint for $857M

Aug. 5, 2025
By Tamra Sami
No Comments
Lepu Biopharma Co. Ltd. has out-licensed two preclinical T-cell engagers to Shanghai-based newco Excalipoint in a deal worth $857.5 million plus equity interest. Under the deal terms, Excalipoint gains an exclusive global license to CTM-012 and CTM-013, developed by Lepu’s Topabody T-cell engager platform. In exchange, Lepu will receive $10 million up front and up to $847.5 million in development and commercial-based milestones, plus tiered royalties on sales.
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Cancer

Pheon Therapeutics presents new antibody-drug conjugates

Aug. 5, 2025
Pheon Therapeutics Ltd. has identified antibody-drug conjugates comprising antibodies targeting tumor associated antigens covalently linked to cytotoxic drugs through linker reported to be useful for the treatment of cancer.
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T cells attacking cancer cells

Lepu out-licenses T-cell engagers to newco Excalipoint for $857M

Aug. 4, 2025
By Tamra Sami
No Comments
Lepu Biopharma Co. Ltd. has out-licensed two preclinical T-cell engagers to Shanghai-based newco Excalipoint in a deal worth $857.5 million plus equity interest. Under the deal terms, Excalipoint gains an exclusive global license to CTM-012 and CTM-013, developed by Lepu’s Topabody T-cell engager platform. In exchange, Lepu will receive $10 million up front and up to $847.5 million in development and commercial-based milestones, plus tiered royalties on sales.
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Cancer

Systimmune presents ADCs targeting TROP2

Aug. 4, 2025
Systimmune Inc. has synthesized antibody-drug conjugates comprising antibodies targeting tumor-associated calcium signal transducer 2 (TACSTD2; TROP2) covalently linked to cytotoxic drugs through linker reported to be useful for the treatment of cancer.
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Cancer

Mabwell receives IND clearance in US and China

Aug. 4, 2025
No Comments

Mabwell (Shanghai) Bioscience Co. Ltd. announced that its Cadherin-17 (CDH17)-targeting antibody-drug conjugate (ADC), 7MW-4911, has received IND clearance to initiate clinical trials from both the U.S. FDA and China's National Medical Products Administration (NMPA).


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Cancer

Beijing Tide Pharmaceutical identifies nanobody-drug conjugates for lung cancer

July 31, 2025
Beijing Tide Pharmaceutical Co. Ltd. has divulged nanobody-drug conjugates comprising a nanobody targeting B7 homolog 3 (B7-H3, CD276) covalently bound to exatecan through a linker reported to be useful for the treatment of lung cancer.
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