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Home » Topics » Bispecific antibody, BioWorld Science

Bispecific antibody, BioWorld Science
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3D pancreas illustration
Immuno-oncology

New anti-CTGF/PD-1 bispecific antibody outperforms combination therapy in remodeling PDAC microenvironment

July 7, 2025
No Comments
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, primarily due to its dense, desmoplastic and immunosuppressive tumor microenvironment (TME) that hinders the efficacy of immune checkpoint inhibitors such as anti-programmed cell death 1 (PD-1).
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Bispecific antibodies with heavy chain in green and pink, light chain in blue and yellow
Immune

Otsuka licenses Harbour Biomed’s BCMAxCD3 bispecific T-cell engager HBM-7020

June 23, 2025
No Comments
Harbour Biomed Ltd. has established a global strategic collaboration with Otsuka Pharmaceutical Co. Ltd. to advance BCMAxCD3 bispecific T-cell engagers for the treatment of autoimmune diseases.
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3d rendering of bispecific antibodies
Cardiovascular

Diagonal Therapeutics’ DIAG-723 designated orphan drug for hereditary hemorrhagic telangiectasia

June 19, 2025
No Comments
Diagonal Therapeutics Inc.’s DIAG-723 has been awarded orphan drug designation by the FDA for the treatment of hereditary hemorrhagic telangiectasia (HHT). Additionally, the EMA has provided a positive opinion for orphan drug designation, confirming that DIAG-723 meets the criteria for designation as an orphan drug in the E.U.
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Dermatologic

Alys Pharmaceuticals submits CTA for ALY-301 for cold urticaria

June 10, 2025
No Comments
Alys Pharmaceuticals Inc. has submitted a clinical trial application (CTA) to Germany’s Paul-Ehrlich-Institut (PEI) to initiate a phase I/Ib study of ALY-301 in healthy volunteers and patients with cold urticaria, a subtype of chronic inducible urticaria.
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Handshake with globe background and digital overlay
Immuno-oncology

Epimab sells bispecific T-cell engager to Juri in $210M deal

June 4, 2025
By Marian (YoonJee) Chu
No Comments
Epimab Biotherapeutics Inc. licensed out a development-ready KLK2/CD3 bispecific T-cell engager (TCE) for advanced prostate cancer to Juri Biosciences Inc. through a potential $210 million deal.
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3D rendering of skin cells and elastin with collagen layer
Dermatologic

Teva begins IND-enabling studies with BD-9

May 28, 2025
No Comments
Teva Pharmaceutical Industries Ltd. has commenced IND-enabling studies with BD-9, a dual-specific multibody targeting thymic stromal lymphopoietin (TSLP) and interleukin-13 (IL-13). By simultaneously blocking two key drivers of TH2-driven inflammation, BD-9 has the potential to improve outcomes for patients with conditions such as atopic dermatitis and asthma.
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Lungs
Respiratory

IBI-3002 exerts potent anti-inflammatory activity in preclinical asthma models

May 23, 2025
No Comments
Interleukin-4 receptor α (IL-4Rα), a shared receptor subunit for both IL-4 and IL-13, along with thymic stromal lymphopoietin (TSLP), are key drivers of the type 2 inflammatory cascade involved in asthma and other inflammatory disorders.
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Respiratory

Zymeworks’ bispecific antibody relieves airway inflammation in asthma and COPD models

May 21, 2025
No Comments
Chronic obstructive pulmonary disease (COPD) is a prevalent and heterogeneous respiratory disorder with limited effective treatments. IL-33 and IL-4Rα are key mediators of airway inflammation in COPD and hence represent potential therapeutic targets.
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3D illustration of cancer in crosshairs
Immuno-oncology

Integrating antibody therapy and oncolytic virotherapy enhances effects

May 14, 2025
No Comments
Current anticancer approaches, such as antibody or CAR T-cell therapies, rely on targeting tumor-associated antigens rather than tumor-specific antigens, with the consequent on-target, off-tumor effects.
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Immuno-oncology

Aptevo Therapeutics advances APVO-711 for solid tumors

May 9, 2025
No Comments
Aptevo Therapeutics Inc. is advancing APVO-711, its bispecific antibody targeting PD-L1 x CD40 that combines checkpoint inhibition with immune activation in a single molecule.
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