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Home » Topics » Drugs » Monoclonal antibody

Monoclonal antibody
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Human body skeleton with DNA science background art
Endocrine/metabolic

Nextcure’s anti-Siglec-15 mAb improves bone architecture in murine model

July 25, 2025
No Comments

Nextcure Inc. has unveiled new preclinical data supporting the therapeutic potential of NC-605, a new anti-Siglec-15 antibody, in treating osteogenesis imperfecta, a rare genetic disorder characterized by fragile bones and frequent fractures. 


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Sino to acquire Lanova and pipeline for up to $950M

July 22, 2025
By Marian (YoonJee) Chu
No Comments
Sino Biopharmaceutical Ltd. agreed to fully acquire Lanova Medicines Ltd. by buying an additional 95.09% stake in Lanova at a valuation of up to $950.92 million. Considering Lanova’s estimated cash and deposit of $450 million, Hong Kong-headquartered Sino agreed to pay $500.9 million to Lanova on the date of the transaction, set to close within 30 days of all conditions being satisfied, or July 31, 2025.
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Skin irritation on hands

Livzon’s IL-17A/F meets phase III endpoints in plaque psoriasis ​

July 22, 2025
By Tamra Sami
No Comments
Livzon Mabpharm Inc.’s anti-IL-17A/F monoclonal antibody, LZM-012, met the primary endpoint in a phase III trial in moderate to severe plaque psoriasis. Conducted at Fudan University’s Huashan Hospital, the phase III multicenter, randomized, double-blind, active-controlled (secukinumab) trial enrolled 926 patients with moderate to severe plaque psoriasis.
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Lungs

Still no scare for Ohtuvayre: Roche IL-33 COPD data mixed

July 21, 2025
By Randy Osborne
No Comments
The fate of IL-33-targeting astegolimab will be determined by talks with regulators, after Roche AG’s Genentech unit rolled out mixed results from a pair of studies testing the compound vs. placebo on top of standard-of-care (SOC) maintenance therapy in subjects with moderate to very severe chronic obstructive pulmonary disease (COPD).
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Sino to acquire Lanova and pipeline for up to $950M

July 16, 2025
By Marian (YoonJee) Chu
No Comments
Sino Biopharmaceutical Ltd. agreed to fully acquire Lanova Medicines Ltd. by buying an additional 95.09% stake in Lanova at a valuation of up to $950.92 million. Considering Lanova’s estimated cash and deposit of $450 million, Hong Kong-headquartered Sino agreed to pay $500.9 million to Lanova on the date of the transaction, set to close within 30 days of all conditions being satisfied, or July 31, 2025.
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Close up of a porous bone structure

More to go: Mereo and Ultragenyx wilt as phase III rolls on

July 10, 2025
By Lee Landenberger
No Comments
Ultragenyx Pharmaceutical Inc. and Mereo Biopharma Group plc, along with investors, had hoped for an early halt to the phase III study of setrusumab in treating brittle bones. They didn’t get it, as the clinical trial’s data monitoring committee wants the study to roll on through its final analysis.
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Infection

Monoclonal antibody cross-neutralizes Nipah and Hendra viruses by targeting conserved regions

July 10, 2025
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Nipah (NiV) and Hendra (HeV) viruses, two closely related members of the Henipavirus genus, continue to raise global concern due to their high mortality rates and potential for zoonotic spillover. Despite repeated outbreaks, there are still no licensed antiviral treatments targeting these pathogens, either for control or prevention.


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China approves Simcere’s suvemcitug for ovarian cancer

July 8, 2025
By Tamra Sami
No Comments
China’s National Medical Products Administration gave the green light to Simcere Pharmaceutical Group Ltd.’s Enzeshu (suvemcitug) for treating recurrent ovarian cancer, fallopian tube cancer, or primary peritoneal cancer in combination with paclitaxel, liposomal doxorubicin, or topotecan in adults who have received at least one systemic therapy after platinum resistance.
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China approves Simcere’s suvemcitug for ovarian cancer

July 7, 2025
By Tamra Sami
No Comments
China’s National Medical Products Administration gave the green light to Simcere Pharmaceutical Group Ltd.’s Enzeshu (suvemcitug) for treating recurrent ovarian cancer, fallopian tube cancer, or primary peritoneal cancer in combination with paclitaxel, liposomal doxorubicin, or topotecan in adults who have received at least one systemic therapy after platinum resistance.
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Illustration of monoclonal antibody hovering between doctor's hands
Immune

Oxion’s anti-OX40L antibody shows potential for disease-modifying effects

July 7, 2025
No Comments
The OX40/OX40L costimulatory pathway is crucial for effective T-cell activation and is inducibly expressed in response to immunological stimulation. Targeting OX40L has demonstrated safety and efficacy in preclinical studies using nonhuman primate models of kidney and heart transplantation.
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