Forkhead box protein L2 (FOXL2) is a protein involved in ovary development and maintenance, among other functions. Mutations in its gene are involved in ovarian failure and granulosa cell tumors, being the latter a rare cancer type caused in most cases by the C134W mutation (c.402C>G) in the FOXL2 gene. By using CRISPR/Cas9 technology, researchers from Spain have aimed to remove this mutation in the FOLX2 gene from granulosa tumor cells.

Venetoclax, a selective Bcl-2 inhibitor, has proven effective in chronic lymphocytic leukemia (CLL), but genetic mutations or adaptive changes over time can result in resistance to treatment and disease relapse. Researchers from Newave Pharmaceutical Inc. and collaborators described the preclinical efficacy of LP-118, a Bcl-2 inhibitor, in venetoclax-resistant models of CLL.

The absent, small or homeotic-like 1 (ASH1L) protein regulates the expression of HOXA genes, which are critical for the development of MLL1 translocations frequently found in leukemia patients. Knockdown of ASH1L leads to growth arrest and apoptosis of leukemia cells, thereby inhibiting leukemia progression suggesting that ASH1L can be considered as a therapeutic target in this setting.

Chinese researchers and their collaborators have published data on the bifunctional antibody JS-201, which exerts dual targeting of PD-1 and TGF-β signaling, for the potential treatment of cancer and its protective role against radiation-induced lung injury.