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BioWorld - Saturday, May 17, 2025
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Other news to note for May 16, 2025

May 16, 2025
Additional early-stage research and drug discovery news in brief, from: AB Science, Capsida Biotherapeutics, Channel Therapeutics, Excision Biotherapeutics, In8bio, Precision Biosciences.
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Free access to BioWorld coronavirus articles

May 16, 2025
The articles in this collection are from BioWorld’s ongoing coverage of the COVID-19 coronavirus pandemic. They are available for free with registration. Note that we have added three critical tables, which are continuously updated:

Vaccines and therapeutics in development
Diagnostics with U.S. FDA emergency use authorization
Clinical trials of biopharma products affected by COVID-19
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Cancer

Pillai Universal discovers new protein kinase inhibitors

May 16, 2025
Pillai Universal LLC has prepared and tested compounds acting as protein kinase inhibitors reported to be useful for the treatment of cancer.
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Cancer

Halda Therapeutics identifies new heterobifunctional compounds

May 16, 2025
Halda Therapeutics LLC has synthesized heterobifunctional compounds able to bind both androgen receptor and bromodomain-containing protein 4 (BRD4; HUNK1) reported to be useful for the treatment of cancer.
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Cancer

ADC Therapeutics patents new anti-NaPi2b conjugates

May 16, 2025
ADC Therapeutics SA has described antibody-drug conjugates comprising antibody targeting sodium-dependent phosphate transport protein 2B (SLC34A2; NaPi-2b) covalently linked to exatecan through a linker reported to be useful for the treatment of ovarian cancer and non-small-cell lung cancer (NSCLC).
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Cancer

Gen1e Lifesciences presents new ERK inhibitors

May 16, 2025
Gen1e Lifesciences Inc. has disclosed drugs targeting extracellular-regulated kinase (ERK) reported to be useful for the treatment of cancer, inflammatory disorders, autoimmune and lung diseases.
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Cancer

Starg (Wuhan) Pharmaceutical Technology describes new DGK-ζ inhibitors

May 16, 2025
Starg (Wuhan) Pharmaceutical Technology Co. Ltd. has discovered compounds acting as diacylglycerol kinase ζ (DGK-ζ) inhibitors reported to be useful for the treatment of cancer.
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Photomicrograph of hepatocellular carcinoma
Cancer

RGS14: An endogenous inhibitor of G protein-coupled receptors that promotes hepatocellular carcinoma

May 16, 2025
No Comments
Hepatocellular carcinoma (HCC), which accounts for up to 80% of cases of primary liver cancer, is typically diagnosed in an advanced stage, meaning a poor prognosis. Understanding what drives progression may help identify proteins and pathways that can be targeted to slow down the disease.
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Cancer

SY-13380: A novel menin/KMT2A inhibitor for aggressive leukemia

May 16, 2025
No Comments
Acute myeloid leukemia (AML) harboring KMT2A rearrangements (KMT2A-r) represents a highly aggressive disease subtype, characterized by poor therapeutic response and a high risk of relapse.
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Cancer cell targeted in crosshairs
Cancer

CDK9 identified as a potential therapeutic target in parameningeal alveolar rhabdomyosarcoma

May 16, 2025
No Comments
Rhabdomyosarcoma is an aggressive soft tissue cancer that primarily affects children, accounting for around 7% of all childhood tumors.
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