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Cancer

Boehringer Ingelheim describes new PHGDH inhibitors

July 11, 2024
Boehringer Ingelheim Pharma GmbH & Co KG has synthesized D-3-phosphoglycerate dehydrogenase (3-PGDH; PHGDH) inhibitors reported to be useful for the treatment of cancer, autoimmune disease, infections and inflammation.
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Art concept for tumor
Cancer

EPHB2/ABL1 axis identified as therapeutic target in ependymoma

July 11, 2024
Ependymoma is a brain cancer that occurs during childhood and is usually resistant to cytotoxic therapy. Molecular profiling has helped in better understanding the mechanisms behind the disease and has unveiled EPH receptor B2 (EPHB2) as a critical player in driving disease.
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3D illustration of tumor
Immuno-oncology

Ipsen licenses Foreseen’s FS-001 ADC for solid tumors

July 11, 2024
Ipsen SA and Foreseen Technology (Beijing) Co. Ltd. have entered into an exclusive global licensing agreement for FS-001, an antibody-drug conjugate (ADC) that targets a novel tumor-associated antigen highly expressed across a range of solid tumors that was identified through the application of Foreseen’s proprietary proteomic platforms.
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Neurology/psychiatric

XYY-CP1106 for Alzheimer’s demonstrates promising preclinical safety profile

July 11, 2024
Zhejiang University of Technology has reported preclinical safety data for the novel multitargeting compound XYY-CP1106, being developed for the treatment of Alzheimer’s disease (AD). XYY-CP1106 is a multitargeted anti-AD compound that has previously demonstrated strong monoamine oxidase B (MAO-B) inhibition (IC50=14.7 nM), high Fe3+ chelation (pFe3+=18.04), no in vitro cytotoxicity and protection against cellular oxidative damage.
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Stomach and esophagus
Cancer

KIAA1429-driven RASD1 down-regulation promotes gastric cancer progression

July 11, 2024
N6-Methyladenosine (m6A) is the most widely distributed RNA modification in eukaryotes and its dysregulation has been tied in gastric cancer protumorigenic processes, as well as drug resistance and metastasis. Vir-like m6A methyltransferase associated, also known as KIAA1429, is a crucial regulator of the m6A complex, and thus hypothesized to be involved in the progression of gastric cancer.
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Illustration demonstrating parts of the ear
Drug design, drug delivery & technologies

A gene therapy could restore hearing in adults

July 11, 2024
By Mar de Miguel
Patients with congenital hearing loss could benefit from a gene therapy currently in development. Although there are approaches that could reverse the process in children and young people before it becomes severe, so far, adults do not have any treatment that prevents the progressive deterioration of auditory sensory cells caused by this disease.
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