KRAS is a GTP-binding protein involved in cell growth control that requires post-translational farnesylation to be active. KRAS G12D mutations are mostly associated with pancreatic, colorectal and non-small-cell lung cancers and occur less commonly in other cancers. There are currently no therapies approved to specifically target this mutation.
At the IDWeek 2023 infectious disease conference held last week in Boston, fungal infections got the audience’s attention during the session titled, “The antifungal evolution: novel strategies for a changing world.” With the emergence of some resistant pathogens such Candida auris and the growing disease burden in the population at risk for life-threatening fungal infections, these pathogens are more than ever standing out within the infectious diseases arena.
New and updated preclinical data presented at the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics conference in Boston, by: Astrazeneca, Boundless Bio, Corbus Pharmaceuticals, Fusion Pharmaceuticals, Phio Pharmaceuticals, Scorpion Therapeutics.
Jazz Pharmaceuticals plc has described tricyclic phthalazines acting as son of sevenless homolog 1 (SOS1)/GTPase KRAS interaction inhibitors reported to be useful for the treatment of cancer.
Dmtc Ltd. has divulged macrophage infectivity potentiator (Mip)-related protein (bacterial) inhibitors reported to be useful for the treatment of Q fever.
Kyoto University has disclosed compounds and their nanoparticles acting as radiosensitizers for radiotherapy reported to be useful for the treatment of cancer.
Cimeio Therapeutics Inc. has entered into a preclinical research collaboration with a researcher at the University of Pennsylvania (Penn) to research and evaluate a novel universal immunotherapy with potential to treat multiple blood and bone marrow cancers.
Researchers from Shanghai Jiao Tong University and affiliated organizations presented data from a study that aimed to identify new pathogenic genes for autosomal dominant hypotrichosis (hair loss).