Artelo Biosciences Inc. has completed a pre-IND meeting with the FDA regarding the manufacturing, preclinical and clinical development plan for ART-26.12.
Researchers from the Royal Melbourne Hospital and Peter MacCallum Cancer Centre, along with other affiliated organizations, have published details on the synthesis and in vivo characterization of a novel series of 177Lu-labeled peptides with strong binding affinity to the cholecystokinin CCK2 receptor, an important molecular target which is highly expressed in a range of cancers.
Proteros Biostructures GmbH has established a new collaboration with Orion Corp. The two companies are engaging in a joint multitarget collaboration for early-stage drug discovery projects in oncology and pain using Proteros’ discovery platform, and now have decided to combine their expertise to assemble a chemically diverse small-molecule library collection. The nonexclusive agreement enables Proteros to exclusively offer access to this high throughput screening (HTS) library to all its clients.
Beam Therapeutics Inc. has released new preclinical data demonstrating the ability of its in vivo drug candidate, BEAM-302, to directly correct the PiZ mutation, the primary disease-causing mutation associated with severe α1-antitrypsin deficiency (AATD).
In multiple sclerosis (MS), macrophages and microglia play a dual role that could be used to treat this neurodegenerative disease. These cells promote inflammation that demyelinates neurons but also sweep away the debris of damaged myelin and produce neurotrophic factors that would allow its restoration. According to a group of scientists from the University of Hasselt in Belgium, damage or repair depends on a double switch that combines the action of two enzymes, one that desaturates and another that elongates fatty acids. By reducing the levels of these enzymes, phagocytic cells would replenish the myelin instead of engulfing it.
Conjugated oligoelectrolytes (COEs) have recently emerged as potential broad-spectrum antibiotics with promising selectivity that is irrespective of metabolic state, including dormant and biofilm-associated bacteria. Researchers from National University of Singapore, University of California Santa Barbara, and Walter Reed Army Institute of Research have sought to identify novel cationic antimicrobial COE candidates.
Sichuan Haisco Pharmaceutical Co. Ltd. has described N6-adenosine-methyltransferase catalytic subunit (METTL3) inhibitors reported to be useful for the treatment of cancer.
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