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Home » Topics » Biomarkers, BioWorld Science

Biomarkers, BioWorld Science
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Photomicrograph of hepatocellular carcinoma
Cancer

RGS14: An endogenous inhibitor of G protein-coupled receptors that promotes hepatocellular carcinoma

May 16, 2025
No Comments
Hepatocellular carcinoma (HCC), which accounts for up to 80% of cases of primary liver cancer, is typically diagnosed in an advanced stage, meaning a poor prognosis. Understanding what drives progression may help identify proteins and pathways that can be targeted to slow down the disease.
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Biomarkers

GPR171 is a prognostic marker in cervical cancer

May 14, 2025
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Recent evidence has shown that G protein-coupled receptor 171 (GPR171) may be a key T-cell checkpoint in tumor immunity.
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Cancer

PSMD14: a protector protein that jeopardizes bladder cancer patients

May 13, 2025
No Comments
Some deubiquitinating enzymes may help protect against cancer, but others appear to promote it. Researchers from the First Affiliated Hospital of Zhejiang University have discovered that the deubiquitinator PSMD14 helps drive bladder cancer, and they have defined at least one signaling pathway through which it works, opening up possibilities for development of new treatments.
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Photomicrograph of fine needle aspiration cytology of a pulmonary nodule showing adenocarcinoma, a type of non-small-cell carcinoma.
Biomarkers

The GTPase GIMAP8 implicated in lung adenocarcinoma

May 12, 2025
No Comments
Researchers at Jilin University and collaborators combed through data in the public Cancer Genome Atlas and identified a potential target for lung adenocarcinoma.
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Close up of woman's bulging eyes
Ocular

Identifying NNMT as a therapeutic target in an autoimmune eye disorder

May 9, 2025
No Comments
Individuals with autoimmune diseases affecting the thyroid can suffer eye complications in the form of Graves’ orbitopathy, in which inflammation in and around the orbit leads to eyelid retraction, eye bulging and other symptoms.
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Photomicrograph of hepatocellular carcinoma
Biomarkers

SLC25A19 predicts prognosis in hepatocellular carcinoma

May 8, 2025
No Comments
Solute carrier family 25 member 19 (SLC25A19) is a transporter protein of thiamine pyrophosphate across cellular membranes, which is needed as a cofactor for multiple metabolic enzymes and is important for homeostasis regulation. It was hypothesized that SLC25A19 may be a pan-cancer marker and a therapeutic target, and more concretely in hepatocellular carcinoma (HCC).
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Brain and DNA
Biomarkers

Variants in MED16 gene cause intellectual disability MEDopathy

April 28, 2025
The Mediator complex is a system that regulates protein-coding gene transcription, where mediator of RNA polymerase II transcription subunit 16 (MED16) is a subunit belonging to this system. Pathogenic genetic variants in Mediator complex subunits usually lead to neurodevelopmental and neurodegenerative diseases with a variety of clinical symptoms, usually designated as MEDopathies.
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Brain and blood cells
Biomarkers

Plasma ANG2 predicts poor outcomes after traumatic brain injury

April 17, 2025
Investigators from the University of Pennsylvania have presented data regarding the relationship of angiopoietin-2 (ANG2) and its prognostic impact on traumatic brain injury (TBI). The ANG2 plasmatic levels were measured in patients with TBI (n=362), orthopedic injury controls (n=89) and healthy controls (n=64).
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Art concept for medical research
Substance use & poisoning

Ignite Biomedical, Liquid Biosciences discover new biomarkers for substance use disorder

April 9, 2025
Ignite Biomedical Inc. and Liquid Biosciences have announced the discovery of biomarkers to diagnose substance use disorder (SUD). The set of biomarkers includes some that have not previously been associated with addiction and spans all 6 SUDs (opioid, cocaine, methamphetamine, alcohol, nicotine and cannabis use disorders).
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Cancer cells under magnifying glass
Biomarkers

CSPG4 expression discerns EBSCC from conventional ESCC

April 8, 2025
Esophageal basaloid squamous cell carcinoma (EBSCC) is a rare type of esophageal squamous cell cancer (ESCC) characterized by basaloid features and considered to be more aggressive than ESCC. RNA sequencing was performed from 20 pure EBSCC and 11 poorly differentiated ESCC samples; researchers identified chondroitin sulfate proteoglycan 4 (CSPG4) as a potential marker of EBSCC at the mRNA level, which was verified by immunohistochemistry in these same samples.
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