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Home » Topics » New compound, BioWorld Science

New compound, BioWorld Science
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Illustration of antibodies attacking the thyroid
Endocrine/metabolic

Crinetics’ TSHR antagonist demonstrates efficacy in thyroid autoimmune disorders

July 21, 2025
No Comments
Graves disease (GD)-associated hyperthyroidism is an autoimmune disorder characterized by the presence of autoantibodies that stimulate the thyroid-stimulating hormone receptor (TSHR), leading to excessive production of thyroid hormones.
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Cancer cell in the cross-hairs
Cancer

First dual SHP2/FGFR inhibitor demonstrates potent preclinical antitumor activity

July 10, 2025
No Comments
Targeting SHP2 has emerged as a promising approach for treating cancers driven by receptor tyrosine kinases. Although allosteric SHP2 inhibitors have shown strong antitumor activity in preclinical studies, their clinical efficacy as monotherapies has been limited. Recent studies indicate that combining SHP2 inhibitors with kinase inhibitors may enhance treatment effectiveness and help overcome therapeutic resistance.
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Woman and 3D brain
Neurology/psychiatric

[68Ga]STZL-730 is promising approach for imaging of neuroinflammation

July 9, 2025
No Comments
Neuroinflammation is a common hallmark in several neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases, among others, where TREM2 (triggering receptor expressed on myeloid cells 2) is a crucial member involved in this biological process and is mainly expressed in microglial cells, being thus an attractive target for diagnostic imaging.
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Mantle cell lymphoma
Cancer

[161Tb]Tb-BL34L20S, new radiotracer targeting CXCR4 for cancer

July 8, 2025
No Comments
A team of researchers at the University of British Columbia investigated the potential of radiopharmaceutical therapy based on Terbium-161 (161Tb) both in vitro and in vivo using a novel tracer, [161Tb]Tb-BL34L20S, which uses the C-X-C chemokine receptor type 4 (CXCR4)-targeting peptide BL34L20S labeled to 161Tb.
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Microscopic image of clear cell carcinoma, the most common type of renal cell carcinoma.
Cancer

[68Ga]NXK-44 radiotracer arises as a promising agent for RCC

July 3, 2025
No Comments
Chinese researchers from Huazhong University of Science and Technology have developed a novel carbonic anhydrase IX (CAIX)-targeting radiotracer, [68Ga]NXK-44, for the imaging of hypoxic tumors and renal cell carcinoma (RCC).
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Beaker and radioactive icons
Cancer

Vitsgen Therapeutics presents new radiotheranostics

June 30, 2025
No Comments
Vitsgen Therapeutics Inc. recently provided details on the preclinical characterization of a new prostate-specific membrane antigen (PSMA)-targeted radiotheranostic agent, [177Lu]PSMA-VG-01, for the treatment of metastatic castration-resistant prostate cancer.
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Microscope with laptop displaying histology image.
Diagnostics

MUC1-C-targeted near-infrared imaging agent for fluorescence-guided surgery of cancer

June 26, 2025
No Comments
Researchers from Sagittide Therapeutics Co. Ltd. and Shanghai Jiao Tong University have presented results of early studies with a novel MUC1-C-targeted near-infrared imaging agent – SAG-602 – for fluorescence-guided surgery of cancer.
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Cancer

New CAIX-targeting 68Ga/177Lu theranostic pair for clear cell renal cell carcinoma

June 25, 2025
No Comments
At the recent meeting of the Society of Nuclear Medicine and Molecular Imaging, Chinese Academy of Medical Sciences and Peking Union Medical College scientists co-presented a carbonic anhydrase IX (CAIX)-targeting 68Ga/177Lu theranostic pair for clear cell renal cell carcinoma (ccRCC) and its preclinical evaluation.
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Close up of senior man holding wrist of arthritic hand
Musculoskeletal

CXCR7 agonist to mitigate rheumatoid arthritis

June 16, 2025
No Comments
Researchers at Ileadbms Co. Ltd. have announced promising results of their novel drug IL-21120033 in a preclinical model of rheumatoid arthritis. The drug acts as a selective agonist of the chemokine receptor CXCR7.
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Doctor points at molecular structure
Cancer

Chinese researchers describe first-in-class PRMT1 degrader

May 30, 2025
No Comments
PRMT1 is a key enzyme that catalyzes asymmetric dimethylation of arginine residues and overexpressed in various cancers and inflammatory diseases. While current PRMT1 inhibitors lack specificity and effectiveness, targeted degradation of PRMT1 offers a potential strategy to treat PRMT1-driven conditions and explore its nonenzymatic roles.
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