An oral drug has shown promise for treating metabolic syndrome in mouse models by selectively blocking the production of free radicals in the mitochondria, a research group has found. The study, carried out by a group led by Martin Brand, Professor Emeritus at the Buck Institute for Research on Aging, could lead to treatments that tackle the underlying causes of metabolic syndrome and multiple other conditions linked to aging.
The unprecedented rise in life expectancy has made advances in the understanding of biological hallmarks of aging, at both the molecular and cellular levels, essential. A joint effort between Baylor College of Medicine, Genentech Inc., Stanford University and collaborating institutions has led to the release of the first Aging Fly Cell Atlas (AFCA) as a result of a deep dive analysis of 163 different cell types in Drosophila melanogaster, the common fruit fly.
A nutritional supplement to reduce the effects of aging might not be a pill of eternal youth, but it could reduce many of the problems of getting old while maintaining good health. The first step to achieve this is included in a study led by scientists from Columbia University. They have set their sights on the amino acid taurine.
Polydeuterated analogues of ambroxol and bromhexine have been reported in a Zywie LLC patent as potentially useful for the treatment of aging, Parkinson’s and Alzheimer’s diseases, dementia with Lewy bodies and frontotemporal dementia.
Integrated Biosciences Inc., an early-stage startup that is combining synthetic biology and machine learning in the hunt for drugs that tackle cell senescence, has demonstrated its capabilities in a newly published study in Nature Aging on May 4, 2023, which employed artificial intelligence to identify three novel compounds that are highly selective for Bcl-2 and that exhibit favorable medicinal chemistry profiles.
Integrated Biosciences Inc., an early-stage startup that is combining synthetic biology and machine learning in the hunt for drugs that tackle cell senescence, has demonstrated its capabilities in a newly published study in Nature Aging on May 4, 2023, which employed artificial intelligence (AI) to identify three novel compounds that are highly selective for Bcl-2 and that exhibit favorable medicinal chemistry profiles.
Cells of Saccharomyces cerevisiae, a yeast used as a model for human mitosis, age in two ways. Both genomic instability and the decline of mitochondria cause cells to degenerate and die. The choice of one type or another depends on a network of genes that can be adjusted by bioengineering.
Scientists at the University of Virginia have discovered an anti-aging mechanism mediated by an enzyme that metabolizes alcohol. Alcohol dehydrogenase, which in Caenorhabditis elegans and yeast replaces the rejuvenating effect of autophagy, would reduce age-associated glycerol levels, also promoting longevity in mice and humans.
Thymmune Therapeutics Inc. has secured US$7 million in seed financing to support its work in developing scalable thymic cell therapies to restore immune function in aging and disease.
Compared to the issues that come with, say, a failing liver, skin aging can look like more of a vanity problem. But aging in both tissues, and multiple others, is driven by the same underlying molecular mechanisms. One of those mechanisms is fibrosis, the cross-linking of extracellular matrix (ECM) proteins that leads to tissue stiffening. Anti-aging company Cambrian Biopharma Inc. has argued that stiffening of the ECM should be considered one of the formal hallmarks of aging.
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